ArticleRadiology case reports2026
Laryngeal metastasis from a thumb melanoma after a 5-year disease-free interval: A case of acute airway presentation and review of the literature.
Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Metastatic malignant melanoma to the larynx is an exceptionally rare clinical entity. We report the case of a 55-year-old woman with a history of thumb melanoma treated 5 years prior, who presented with laryngeal dyspnea. Imaging revealed a large, non-enhancing laryngeal mass infiltrating all 3 levels, with thyroid cartilage lysis and an ipsilateral metastatic cervical lymph node. Following emergency tracheotomy, histopathology confirmed metastatic melanoma (HMB-45+, Melan-A+). The patient underwent total laryngectomy with bilateral neck dissection, followed by adjuvant nivolumab immunotherapy. At the 1-year follow-up, she shows no evidence of recurrence with good stoma function and manageable immunotherapy-related fatigue. This case highlights the diagnostic challenges, the potential for aggressive curative treatment in oligometastatic disease, and underscores the need for lifelong surveillance in melanoma patients.
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