ReviewFrontiers in microbiomes2025
Postbiotics and their biotherapeutic potential for chronic disease and their feature perspective: a review.
Review in Frontiers in microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Gut health and microbiome modulation by the heat-killed postbiotic beLP1Frontiers in nutrition · 2026Trial
- Gut-lung axis and microbiome alterations in mycobacterial infections: from pathogenesis to therapeutic potential.Gut microbes · 2026Review
- Protective Effects of Lactobacillus-Derived Probiotics and Postbiotics on Renal and Reproductive Function in Escherichia coli-Infected Rats.Veterinary medicine and science · 2026Article
- Microbiome-Guided Maternal and Child Nutrition: A Structured Narrative Review of Indigenous African Foods, Fermented Foods, and Emerging Evidence.International journal of molecular sciences · 2026Review
- Heat-InactivatedCells · 2026Article
- Integrative Analysis of Gut Microbiota and Metabolome Reveals Health Benefits of Postbiotic Supplementation in Asian Seabass (Biology · 2026Article
- Insights into Microbiota-Vaccine Crosstalk in Humans: Mechanisms, Modulators, and Translational Horizons.Vaccines · 2026Review
- Protective Effect of a Heat-Stabilized Bacteria Probiotic Preparation (VSL#3-HS) in a Mouse Model of Ulcerative Colitis Induced by Dextran Sulfate Sodium.Molecular nutrition & food research · 2026Article
- Restoring Microbial Signaling: A Metabolite-Immune-Redox Framework for Postbiotic Host-Directed Interventions.Medical sciences (Basel, Switzerland) · 2026Review
- Postbiotics in Functional Foods: Preparation-Based Characterization, Gut-Brain Axis Interactions, and Translational Perspectives.Foods (Basel, Switzerland) · 2026Review
- Postbiotics as Multifunctional Bioactives: Mechanistic Insights and Translational Applications in Host Physiology and Microbial Ecosystem Modulation.Microorganisms · 2026Review
- Probiotics and Postbiotics in Life-Style Disease Management: A Comprehensive Review on the Technologies in the Era of Omics and Artificial Intelligence.Probiotics and antimicrobial proteins · 2026Review
- The Microbiota-Endometriosis Axis: An Immune-Endocrine Integration Model and Emerging Therapeutic Targets.International journal of molecular sciences · 2026Review
- Postbiotics: Novel Modulators of Gut Health, Metabolism, and Their Mechanisms of Action.Probiotics and antimicrobial proteins · 2026Review
- Postbiotics and paraprobiotics in food biochemistry mechanisms stability and nutritional applications.NPJ science of food · 2026Review
- Postbiotics as Emerging Strategy Targeting Obesity- and Aging-Related Breast Cancer-Prospects in Prophylaxis and Therapy.Life (Basel, Switzerland) · 2026Review
- Review
- Functional Equivalence of Heat-Inactivated (HI) and Live Probiotic RSB11 in Suppressing Inflammation: Expanding Formulation and Application Potential.bioRxiv : the preprint server for biology · 2026Article
- Beneficial impacts of postbiotic components -- Crosstalk between gut and organs.Current research in food science · 2026Review
- Untargeted metabolomics reveals distinct metabolic profiles and putative bioactive metabolites in cell-free supernatants of food-grade microorganisms.Frontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postbiotics, which are bioactive compounds derived from the metabolic processes of probiotics, are gaining recognition as a promising alternative for managing chronic diseases without the need for live microorganisms, positioning them as a valuable strategy in biotherapeutics that offers both curative and preventive techniques in modern medicine. This paper provides a comprehensive review of the potential health benefits of postbiotics, particularly concerning noncommunicable diseases like diabetes, cancer, obesity and cardiovascular conditions, which present significant global health challenges. We explore the various mechanisms by which postbiotics exert their beneficial effects, including immune modulation to enhance the body's immune response and reduce inflammation, as well as improving gut barrier function to maintain gut integrity and prevent increased intestinal permeability. Additionally, the antioxidant properties of postbiotics play a critical role in neutralizing oxidative stress, which is linked to the progression of chronic diseases. Despite the encouraging insights into their health benefits, we highlight the urgent need for further research to clarify the specific roles of different postbiotic components. A deeper understanding of these mechanisms is essential for developing targeted preventive healthcare applications, and by advancing this knowledge, we aim to create innovative strategies that could significantly enhance health outcomes for at-risk populations. Ultimately, integrating postbiotics into health interventions has the potential to improve preventive care and contribute to the overall well-being of affected individuals and communities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.