ArticlePrenatal diagnosis2026
First-Trimester Down Syndrome Screening in Renal-Transplanted Pregnant Women: Blood Creatinine Levels Impact False-Positive Rate.
Article in Prenatal diagnosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOver the past few decades, several thousand pregnancies following kidney transplantation have been monitored but few studies have reported on first-trimester Down syndrome screening. This study aimed to assess the performance of such screening and its relationship with renal function.
methodWe retrieved data on 16 pregnancies after kidney transplantation and 30 controls matched for age, weight and gestational age. First-trimester blood creatinine levels were systematically researched. Among other variables, multiples of the median (MoM) values for free-βhCG, pregnancy-associated plasma protein-A (PAPP-A), nuchal translucency were compared. After statistical review, we combined our cases group with that of a previous study to obtain a cohort of 27 post-transplantation pregnancies to explore correlations between variables.
resultsMedian values of fβ-hCG MoM of cases and controls were significantly different (2.02 vs. 0.92; p < 0.001) whereas those of PAPP-A and NT MoM were not. Screen positive rate (SPR) were respectively 44% and 17% (cut-off 1/1000). Linear regressions were observed for fβ-hCG MoM and creatinine, but not for PAPP-A, in our initial case group (r = 0.699, p = 0.025) and the merged group (r = 0.724, p < 0.001).
conclusionWe confirmed a specific profile for first-trimester screening variables in first-trimester post-transplantation pregnancies and the impact of renal function, through creatinine levels, on SPR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.