Evidence map›Paper›PMID 41852169›Full record

ArticleChemistry & biodiversity2026

Vitex Simplicifolia Abates Cadmium-Induced Cardiotoxicity Through Antioxidant Activity and Keap1 Targeting.

Ifeoma F Chukwuma, Okechukwu Ignatius Eze, Ogechukwu Colet Okeke, Victor O Apeh, Timothy Prince Chidike Ezeorba, Chima Okafor

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ifeoma F ChukwumaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State, Nigeria.ORCID https://orcid.org/0000-0001-9629-213X
Okechukwu Ignatius EzeTeesside University International Business School, Middlesbrough, UK.
Ogechukwu Colet OkekeDepartment of Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Enugu State, Nigeria.
Victor O ApehDepartment of Applied Sciences, Federal University of Allied Health Sciences, Enugu State, Nigeria.
Timothy Prince Chidike EzeorbaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Enugu State, Nigeria.
Chima OkaforDepartment of Genetics and Biotechnology, Faculty of Biological Sciences, University of Nigeria, Enugu State, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the cardioprotective potential of Vitex simplicifolia methanol extract (VSME) and explored its underlying mechanisms of action. Twenty-five male rats were assigned to five groups (n = 5). Group 1 served as the normal control, while groups 2-5 were exposed to 5 mg/kg body weight of cadmium chloride (CdCl

Indexed as

AntioxidantsCadmiumCardiotonic AgentsCardiotoxicityKelch-Like ECH-Associated Protein 1Plant ExtractsVitexAnimalsMaleMolecular Docking SimulationOxidative StressRatsRats, Sprague-DawleyAntioxidantsCadmiumCardiotonic AgentsKEAP1 protein, ratKelch-Like ECH-Associated Protein 1Plant Extractsand vitex simplicifoliaantioxidantscardiac markerscardiovascular diseasesKelch‐like ECH‐associated protein 1

Identifiers

PMID41852169
PMCPMC13000684

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.