Evidence map›Paper›PMID 41852146›Full record

ArticlePhysiological reports2026

Glycolytic alterations as biomarkers in polycystic kidney disease: A study using a PKD1 knockout model in NRK-52E rat kidney epithelial cells.

Ida Kjær Mieritz, Christoffer Laustsen, Esben Axelgaard, Sofie Rahbek Dorset, Rasmus O Bak, Lotte Bonde Bertelsen

Abstract read
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In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ida Kjær MieritzThe MR Research Center, Dept. of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Christoffer LaustsenThe MR Research Center, Dept. of Clinical Medicine, Aarhus University, Aarhus N, Denmark.
Esben AxelgaardDepartment of Biomedicine, Aarhus University, Aarhus C, Denmark.
Sofie Rahbek DorsetDepartment of Biomedicine, Aarhus University, Aarhus C, Denmark.
Rasmus O BakDepartment of Biomedicine, Aarhus University, Aarhus C, Denmark.
Lotte Bonde BertelsenThe MR Research Center, Dept. of Clinical Medicine, Aarhus University, Aarhus N, Denmark.ORCID 0000-0002-2491-3184

Funding

Innovation Fund Denmark 8056-00010BKaren Elise Jensens Fond (Karen Elise Jensen Foundation) 500043Lundbeckfonden (Lundbeck Foundation) R238-2016-534 3349Lundbeckfonden (Lundbeck Foundation) R272-2027-4023Novo Nordisk Fonden (NNF) 0077911The Danish Cancer Society R279-A16251
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) is a genetic disorder characterized by the formation of fluid-filled cysts in the kidneys, often resulting in progressive renal impairment. Mutations in the PKD1 gene represent the predominant genetic cause of autosomal dominant PKD. Here, we investigated how PKD1 knockout affects glycolytic metabolism in NRK-52E kidney epithelial cells using dynamic nuclear polarization (DNP)-enhanced magnetic resonance spectroscopy (MRS) with hyperpolarized [1-

Indexed as

Epithelial CellsGlycolysisKidneyPolycystic Kidney DiseasesTRPP Cation ChannelsAnimalsBiomarkersCell LineGene Knockout TechniquesLactic AcidL-Lactate DehydrogenaseMonocarboxylic Acid TransportersPyruvic AcidRatsBiomarkersLactic AcidL-Lactate DehydrogenaseMonocarboxylic Acid TransportersPyruvic AcidTRPP Cation ChannelsCRISPRhyperpolarizationkidneyMRSPKD1

Identifiers

PMID41852146
PMCPMC13097512

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.