Evidence map›Paper›PMID 41852140›Full record

ArticleMolecular plant pathology2026

Chemical Priming by Neonicotinoids Unveils CaNEN4 as a Susceptibility Gene Against Phytophthora capsici in Pepper.

Geng Meng, Shujia Wang, Yiheng Hou, Wenqing Li, Shiwei Yang, Tianhao Ge, Chenxue Song, Peng Liu, Wenyi Yang, Gonglian Pang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Geng MengCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Shujia WangCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Yiheng HouCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Wenqing LiCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Shiwei YangCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Tianhao GeCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Chenxue SongCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Peng LiuCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Wenyi YangCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Gonglian PangCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Zhiqi JiaCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Jianbin HuCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Chengwei LiSchool of Agricultural Sciences, Zhengzhou University, Zhengzhou, China.
Yawen ShenCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.
Kaile SunCollege of Horticulture, Henan Agricultural University, Zhengzhou, China.ORCID 0000-0002-2178-994X

Funding

Henan Provincial Colleges and Universities Youth Key Teacher Project 2024GGJS028Henan Provincial Support Program for Science and Technology Innovation Talents in Colleges 26HASTIT022National Natural Science Foundation of China 31801420National Natural Science Foundation of China 32172575National Natural Science Foundation of China 32301848Teaching Reform Project of Henan Agricultural University 2023XJGLX008the Key Scientific Research and Development Project of Henan 252102110184
6 · The paper itself

Abstract

The oomycete Phytophthora capsici causes Phytophthora blight, a major constraint on global pepper production. Our previous observations indicated that pretreating plants with thiamethoxam (TMX) and imidacloprid (IMI) could reduce the incidence of pepper blight, but the underlying mechanisms remained unclear. Here, we investigated how TMX and IMI induced resistance in pepper (Capsicum frutescens) against P. capsici. Both in vitro and in vivo assays demonstrated that TMX and IMI suppressed disease, not by directly impairing pathogen virulence but by inducing systemic resistance in susceptible (Cusheng L09) and resistant (Cusheng 356) pepper cultivars. Split-plant systemic resistance assays showed that TMX/IMI-primed plants developed smaller lesions in both treated and untreated leaves following P. capsici infection. Foliar application of TMX and IMI effectively alleviated disease severity, with IMI showing superior efficacy in attenuating reactive oxygen species (ROS) accumulation, and TMX/IMI priming concomitantly altering the activities of ROS-scavenging enzymes under pathogen challenge. Reverse transcription-quantitative PCR analysis revealed time-dependent changes in defence gene expression, and whole-genome transcriptome profiling highlighted temporal reprogramming of pathogenesis-related genes. Further functional validation identified CaNEN4 as a susceptibility factor. Collectively, our findings reveal that IMI/TMX primes pepper plants with systemic resistance by modulating ROS homeostasis, defence gene expression, and susceptibility gene function, offering novel insights into chemical-induced plant immunity and genetic targets for durable blight resistance in crops.

Indexed as

CapsicumGenes, PlantNeonicotinoidsNitro CompoundsPhytophthoraPlant DiseasesPlant ProteinsDisease ResistanceGene Expression Regulation, PlantImidazolesReactive Oxygen SpeciesimidaclopridImidazolesNeonicotinoidsNitro CompoundsPlant ProteinsReactive Oxygen SpeciesCapsicum frutescenschemical primingPhytophthora capsiciROS homeostasissusceptibility gene

Identifiers

PMID41852140
PMCPMC13097475

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.