Evidence map›Paper›PMID 41852115›Full record

ArticleChemistry & biodiversity2026

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Goyazensolide and Centratherin Isolated From Eremanthus crotonoides by High-Speed Countercurrent Chromatography.

Natalie Giovanna da Rocha Ximenes, Sanderson Dias Calixto, Thatiana Lopes Biá Ventura Simão, Elena B Lassunskaia, Patrícia de Homobono de Brito Moura, Ivana Ramos Correa Leal, Michelle Frazão Muzitano, Shaft Corrêa Pinto

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalie Giovanna da Rocha XimenesLaboratório de Produtos Bioativos, Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Macaé, Brazil.ORCID https://orcid.org/0000-0002-0049-1132
Sanderson Dias CalixtoLaboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.ORCID https://orcid.org/0000-0001-7049-2061
Thatiana Lopes Biá Ventura SimãoLaboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.ORCID https://orcid.org/0000-0001-7563-1833
Elena B LassunskaiaLaboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.ORCID https://orcid.org/0000-0002-6726-273X
Patrícia de Homobono de Brito MouraLaboratório de Produtos Naturais e Ensaios Biológicos, Departamento de Produtos Naturais e Alimentos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-6062-4788
Ivana Ramos Correa LealLaboratório de Produtos Naturais e Ensaios Biológicos, Departamento de Produtos Naturais e Alimentos, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-6917-9323
Michelle Frazão MuzitanoLaboratório de Produtos Bioativos, Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Macaé, Brazil.ORCID https://orcid.org/0000-0003-0155-3240
Shaft Corrêa PintoLaboratório de Produtos Bioativos, Instituto de Ciências Farmacêuticas, Universidade Federal do Rio de Janeiro, Macaé, Brazil.ORCID https://orcid.org/0000-0003-1540-1440

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
6 · The paper itself

Abstract

In this study, bioassay-guided fractionation of the ethanolic extract from Eremanthus crotonoides leaves enabled the isolation of two bioactive sesquiterpene lactones, centratherin and goyazensolide, which were evaluated for their antimycobacterial and anti-inflammatory properties. The extract exhibited MIC

Indexed as

Anti-Bacterial AgentsAntitubercular AgentsLactonesMycobacterium tuberculosisNitric OxideSesquiterpenesAnimalsCountercurrent DistributionDose-Response Relationship, DrugMiceMicrobial Sensitivity TestsMolecular StructurePlant LeavesRAW 264.7 CellsAnti-Bacterial AgentsAntitubercular AgentsLactonesNitric OxideSesquiterpenescentratheringoyazensolidemycobacterium tuberculosissesquiterpene lactones

Identifiers

PMID41852115
PMCPMC13000668

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.