ArticleJournal of Korean gerontological nursing2026
Associations between chronic disease profiles and self-reported adverse drug reactions in community-dwelling older adults: A cross-sectional study.
Article in Journal of Korean gerontological nursing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThis study examined the associations between the types and number of chronic diseases and adverse drug reactions (ADRs) in community-dwelling older adults, aiming to identify high-risk groups and inform nursing strategies for medication safety.
methodsThis cross-sectional analysis included 4,478 adults aged ≥65 years from the 2021 Korea Health Panel Survey. Thirty-one physician-diagnosed chronic diseases were grouped into 11 categories, and the number of diseases was classified as 0~1, 2, 3, 4, or ≥5. ADRs were operationally defined using a single self-report item asking whether participants had experienced side effects from any medications, including over-the-counter drugs. Multiple logistic regression analyses adjusted for sociodemographic and health-related covariates were conducted to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
resultsArthritis and spinal diseases showed the strongest association with ADRs (OR=2.16, 95% CI=1.44~3.24), followed by depression (OR=2.15, 95% CI=1.22~3.79) and cardio-cerebrovascular diseases (OR=1.86, 95% CI=1.25~2.77). ADR risk increased progressively with multimorbidity: OR=1.87 for two diseases, 2.63 for three, 3.15 for four, and 6.22 for ≥five diseases, compared with 0~1 diseases.
conclusionADRs were significantly more likely among older adults with arthritis and spinal diseases, depression, or cardio-cerebrovascular diseases, with risk escalating as multimorbidity increased. Embedding disease type and burden into nursing assessment enables targeted medication review, education, and proactive monitoring. Such nurse-led, collaborative strategies can mitigate drug-related harm and inform policy and training for safe medication use in aging populations.
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