Evidence map›Paper›PMID 41852045›Full record

ArticleEndocrinology and metabolism (Seoul, Korea)2026

Sex Disparity in Suicide Mortality among Patients with Type 2 Diabetes: A Nationwide Population-Based Cohort Study.

Chaiho Jeong, Bongseong Kim, Dae Jong Oh, Tae-Seo Sohn, Kyungdo Han, Hyuk-Sang Kwon

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Article in Endocrinology and metabolism (Seoul, Korea), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Chaiho JeongDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Bongseong KimDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Dae Jong OhWorkplace Mental Health Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Tae-Seo SohnDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kyungdo HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Korea. hkd917@naver.com.
Hyuk-Sang KwonDivision of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. drkwon@catholic.ac.kr.

Funding

Catholic Medical Center Research FoundationMinistry of Science and Information and Communication TechnologyNational Research Foundation of Korea
6 · The paper itself

Abstract

backgruoundSuicide represents a major public health concern in Korea. Patients with type 2 diabetes mellitus (T2DM) are at higher risk for psychological distress and suicide. Although the male-to-female suicide mortality ratio in the general population has remained about 2.3, the specific differences in suicide mortality by sex among individuals with T2DM are not well characterized.

methodsWe performed a nationwide cohort study utilizing the Korean National Health Insurance Service database, identifying 2,526,769 adults with T2DM who underwent health screening from 2015 to 2016. Participants were monitored until the occurrence of suicide or the study endpoint.

resultsDuring a median follow-up of 6.0 years, 5,584 suicide deaths occurred (0.30% in men vs. 0.10% in women). Men exhibited a significantly elevated risk of suicide mortality compared to women (adjusted hazard ratio [HR], 2.88; 95% confidence interval [CI], 2.66 to 3.12). The largest disparity was observed in the ≥80 age group (HR, 3.60; 95% CI, 2.88 to 4.51). However, this sex disparity in suicide mortality was reduced among current smokers and heavy alcohol consumers. Among non-smokers, the HR comparing men to women was 3.51 (95% CI, 3.22 to 3.83), while among current smokers, it was 1.73 (95% CI, 1.40 to 2.14). Similarly, the HR among non-drinkers was 3.04 (95% CI, 2.79 to 3.31), compared with 1.36 (95% CI, 0.85 to 2.18) among heavy drinkers.

conclusionMen with T2DM had a significantly higher risk of suicide mortality than women, exceeding the sex disparity seen in the general population, with the gap further influenced by age and lifestyle factors.

Indexed as

Diabetes Mellitus, Type 2SuicideAdultAgedAged, 80 and overCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedRepublic of KoreaRisk FactorsSex FactorsDiabetes mellitus, type 2Life styleSex disparitySuicide mortality

Identifiers

PMID41852045
PMCPMC13341187

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