Evidence map›Paper›PMID 41852018›Full record

ReviewImmunotherapy2026

Advances in immunotherapy for cytomegalovirus infection following allogeneic hematopoietic stem cell transplantation.

Yu Wang, Jiaying Wu, Xiaobing Huang, Yi Xiao

Abstract readReview
In one paragraph

Review in Immunotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu WangDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
Jiaying WuDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
Xiaobing HuangDepartment of Hematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, P.R. China.
Yi XiaoDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective curative therapy for hematologic malignancies. However, post-transplant cytomegalovirus (CMV) infection remains a common and serious complication, significantly impacting patient prognosis and survival. Currently available antiviral agents are limited by bone marrow suppression, nephrotoxicity, drug resistance, and high cost, highlighting the need for alternative therapeutic strategies. Advances in immunotherapy - including CMV-specific T cells (CMV-CTL), TCR-engineered T cells (CMV-TCR-T), and natural killer (NK) cell therapies - as well as antibody-based approaches and prophylactic vaccines, provide new avenues for CMV management. Future treatment paradigms may integrate antiviral therapy, immunotherapy, and vaccination to improve outcomes in patients experiencing CMV reactivation after transplantation. This review summarizes the current progress of immunotherapeutic strategies for CMV infection following allo-HSCT. Relevant literature was identified through PubMed, Embase, and Web of Science databases, covering the period from January 2000 to December 2025.

Indexed as

CytomegalovirusCytomegalovirus InfectionsHematologic NeoplasmsHematopoietic Stem Cell TransplantationImmunotherapyKiller Cells, NaturalAnimalsAntiviral AgentsHumansT-LymphocytesTransplantation, HomologousAntiviral Agentsadoptive T cell therapyAllogeneic hematopoietic stem cell transplantationcytomegalovirus infectionimmunotherapyvirus-specific T cells

Identifiers

PMID41852018
PMCPMC13094259

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.