Evidence map›Paper›PMID 41851960›Full record

ArticleJournal of medicinal chemistry2026

Synthesis, Radiochemistry, and Preclinical Assessment of the First GPR39 PET Imaging Agent.

Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Ivan Krizan, Mack Miller, Ryan W Fitzgerald, Nishka Amesar, Dundappa Mumbaraddi, Dongqin Zhu, Rita Cervera-Juanes and 3 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bhuvanachandra BhoopalDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Krishna Kumar GollapelliDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Naresh DamukaDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Ivan KrizanDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Mack MillerDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Ryan W FitzgeraldDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Nishka AmesarDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Dundappa MumbaraddiDepartment of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, United States.
Dongqin ZhuDepartment of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Rita Cervera-JuanesDepartment of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Pooja JadiyaDepartment of Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Christopher T WhitlowDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.
Kiran K Solingapuram SaiDepartment of Radiology, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, United States.ORCID 0000-0002-6442-5169

Funding

Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Wake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3M
Distinguishing preexistent and induced epigenetic risk for alcohol use disordersR01AA026278 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CERVERA JUANES, RITA P · 2019 to 2023
$3.2M
Identifying new targets for the treatment of alcohol dependence and relapse: epigenetic analysis of the abstinent brainR01AA027552 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CERVERA JUANES, RITA P · 2020 to 2024
$2.6M
Profiling the alcohol-naive primate cortex to understand the functional role of epigenetics in predisposing the brain to risky alcohol useR01AA032162 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Rita P Cervera Juanes, Kip D Zimmerman · 2025 to 2026
$1.3M
Developing novel PET radioligands to image GPR39 in Alzheimer's DiseaseR21AG089125 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SOLINGAPURAM SAI, KIRAN · 2024 to 2024
$426k
NCATS NIH HHS UL1 TR001420NIAAA NIH HHS R01 AA026278NIAAA NIH HHS R01 AA027552NIAAA NIH HHS R01 AA032162NIA NIH HHS P30 AG072947NIA NIH HHS R21 AG089125
6 · The paper itself

Abstract

GPR39 is a zinc-sensing G protein-coupled receptor with critical roles in neurophysiological and metabolic processes across brain, pancreas, gut, liver, and fat tissues. Activated by extracellular zinc ions, GPR39 is involved in neurodegenerative diseases including altered levels in Alzheimer's disease (AD). Quantifying GPR39 levels

Indexed as

Positron-Emission TomographyRadiopharmaceuticalsReceptors, G-Protein-CoupledAlzheimer DiseaseAnimalsBrainCarbon RadioisotopesHumansMaleMiceMice, KnockoutRadiochemistryTissue DistributionCarbon RadioisotopesGPR39 protein, humanGPR39 protein, mouseRadiopharmaceuticalsReceptors, G-Protein-Coupled

Identifiers

PMID41851960
PMCPMC13402958

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.