Evidence map›Paper›PMID 41851901›Full record

ArticleJournal of animal science and biotechnology2026

Host genomic regulation of ileal Bradyrhizobium abundance modulates eating speed and fat metabolism in birds: a causal mechanism study.

Yang Zhao, Shuangshuang Zhai, Ping Wang, Wenwei Yang, Xinxin Liu, Yuchi Dai, Chengxuan Li, Fei Liu, Ning Yang, Wei Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yang ZhaoSanya Institute, China Agricultural University, Sanya, 572025, China.
Shuangshuang ZhaiSanya Institute, China Agricultural University, Sanya, 572025, China.
Ping WangSanya Institute, China Agricultural University, Sanya, 572025, China.
Wenwei YangSanya Institute, China Agricultural University, Sanya, 572025, China.
Xinxin LiuSanya Institute, China Agricultural University, Sanya, 572025, China.
Yuchi DaiSanya Institute, China Agricultural University, Sanya, 572025, China.
Chengxuan LiSanya Institute, China Agricultural University, Sanya, 572025, China.
Fei LiuSanya Institute, China Agricultural University, Sanya, 572025, China.
Ning YangSanya Institute, China Agricultural University, Sanya, 572025, China.
Wei YanSanya Institute, China Agricultural University, Sanya, 572025, China. wei.yan@cau.edu.cn.

Funding

China Agricultural University Sanya Research Institute SYND-QDJF-04Hainan Provincial Natural Science Foundation of China 325RC806
6 · The paper itself

Abstract

backgroundEating speed is a key eating behavior trait that influences energy intake and fat deposition, yet its regulation by host genetics and gut microbiota remains poorly understood in birds.

resultsWe systematically investigated the interplay among host genetics, gut microbiota, eating speed, and fat deposition in chickens. Phenotypic analyses revealed a positive association between eating speed and abdominal fat, and Mendelian randomization (MR) analysis identified a bidirectional feedback loop in which fat deposition promotes faster eating, which in turn exacerbates fat accumulation. Microbiome and MR analyses highlighted the ileal genus Bradyrhizobium as a causal regulator of both eating speed and fat deposition, with higher abundance reducing abdominal fat, triglyceride levels, and inflammatory markers. Microbiome genome-wide association studies (mGWAS) further identified host genetic variants and candidate genes, including convergent signals at RECK, influencing Bradyrhizobium abundance. Mediation analyses indicated that Bradyrhizobium modulates eating speed partially through its effects on abdominal fat, emphasizing a host-microbe-behavior feedback axis.

conclusionsOur findings reveal a complex interplay among host genetics, gut microbes, and eating behavior, providing mechanistic insights and potential targets for precision interventions to optimize growth and metabolic health in poultry.

Indexed as

Abdominal fatBradyrhizobiumEating speedHost geneticsMendelian randomization

Identifiers

PMID41851901
PMCPMC13001200

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.