SynthesisSystematic reviews2026
Efficacy and safety of stem cell therapy for myocardial infarction and heart failure: an updated systematic review and meta-analysis of randomized controlled trials.
Synthesis in Systematic reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesCardiovascular diseases (CVDs), particularly myocardial infarction (MI) and heart failure (HF), remain global causes of morbidity and mortality, despite the current treatment options. Stem cell therapy (SCT) has emerged as a promising intervention aimed at halting disease progression and promoting cardiac repair. Nonetheless, the clinical efficacy, optimal cell type, delivery method, and safety profile of SCT remain inadequately defined.
methodsThis systematic review and meta-analysis aimed to evaluate the efficacy and safety of SCT in patients diagnosed with ischemic heart disease (IHD) and HF. PubMed, Web of Science, Embase, Scopus, and Science Direct were searched to retrieve randomized controlled trials (RCTs) investigating SCT in patients with MI or HF. Primary outcomes encompassed changes in left ventricular ejection fraction (LVEF), end-diastolic and end-systolic volumes (LVEDV, LVESV), infarct size, functional status, and quality of life measures. Risk ratios were calculated for safety outcomes. Subgroup analyses were executed based on follow-up duration, delivery method, and type of stem cell utilized.
resultsThis review included 35 RCTs comprising 3345 patients (1875 in the SCT group and 1488 in the control group). The SCT indicated that significantly enhanced LVEF at 3, 6, and 12 months (mean difference [MD] = 1.43; 95% CI 0.92 to 1.95; p < 0.00001), while simultaneously reducing LVEDV (MD = - 5.23; 95% CI - 7.55 to - 2.91; p < 0.0001) and LVESV (MD = - 6.91; 95% CI - 9.01 to - 4.82; p < 0.00001). Additionally, infarct size demonstrated significant reductions at 6 and 12 months. Patients undergoing SCT exhibited improvements in functional status and quality of life. The safety profile of SCT indicated that it was well tolerated.
conclusionsSCT appears to be a safe and modestly effective adjunctive therapy for patients with IHD and HF. The standardization of treatment protocols and the conduct of longer-term studies are critical to validate its clinical utility and optimize therapeutic outcomes. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024582716.
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