ArticleBMC public health2026
Associations of sleep, sedentary behavior, and physical activity with incident migraine: a prospective cohort study.
Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundMigraine, a common primary headache disorder, has implicated daily behaviors like sleep, physical activity (PA), and sedentary behavior (SB), yet the findings are inconsistent or remain unclear. This prospective cohort study (2006–2022) aimed to examine the independent and joint associations of sleep, PA, and SB with migraine risk in a general adult population.
methodsData of 484,588 participants without baseline migraine from the UK Biobank were included. Multiple Cox regressions, restricted cubic spline models, and isotemporal substitution model (ISM) were used to assess associations between sleep, PA, SB and incident migraine. A nonlinear association model was used to analyze the correlation between each behavior and magnetic resonance imaging (MRI) brain volume and visualized using the “ENIGMA” tool.
resultsDuring a median follow-up of 13.63 years, 4,380 participants developed migraine. Sleep duration, PA, and SB exhibited distinct nonlinear associations with migraine risk. The risk of migraine was 40% lower in the healthy sleep score group (adjusted hazard ratio (aHR)[95% confidence interval (CI)]: 0.60[0.53, 0.69], p < 0.001) and 23% higher in the high SB group (aHR[95%CI]: 1.23[1.11, 1.37], p < 0.001) compared to the corresponding reference group. Upon examining the joint effects between sleep patterns and SB, individuals with low SB and poor sleep score showed the higher risk of migraine (aHR[95%CI]: 1.98[1.30, 3.02], p = 0.003).
conclusionIn this large prospective cohort, healthier sleep patterns and lower levels of SB were associated with a reduced risk of incident migraine. PA exhibited a complex nonlinear association that did not remain significant in categorical analyses after full adjustment. Notably, sleep duration and SB were associated with structural variations in brain regions implicated in migraine. These findings provide a large-scale epidemiological map linking sleep and SB to migraine risk, and generate the hypothesis that these behaviors are modifiable targets for future preventive intervention trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.