ArticleCell & bioscience2026
METTL3 stabilizes FASN mRNA by mediating m
Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundDiffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma. Fatty acid synthase (FASN) is a key lipogenic enzyme implicated in tumor progression, but its regulation in DLBCL is poorly understood.
methodsThe function of FASN in DLBCL was explored using database analysis, clinical sample analysis, and cellular phenotyping experiments. Candidate m
resultsFASN was highly expressed in DLBCL and positively correlated with poor prognosis. FASN knockdown inhibited the malignant phenotypes in DLBCL cells by suppressing the PI3K/AKT and MAPK/ERK signaling pathways, as well as promoting endoplasmic reticulum (ER) stress. The analysis of FASN mRNA revealed the presence of m
conclusionMETTL3 stabilizes FASN expression through m
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