Chitin nanowhiskers/octacalcium phosphate synergistically reinforced chitosan hydrogel for enhanced bone regeneration.

Mingdong Yan, Yanjing Ou, Ruimin Liu, Changfu Xie, Jiang Chen

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Article in Journal of biological engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Mingdong Yan *Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China. ymingdong@fjmu.edu.cn.

Yanjing Ou *Fujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Ruimin Liu *ORAL Center, Fujian Provincial Governmental Hospital (Affiliated Hospital of Fujian Health College), Fuzhou, 350003, China.

Changfu XieFujian Key Laboratory of Oral Diseases and Fujian Provincial Engineering Research Center of Oral Biomaterial and Stomatological Key Laboratory of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, 350002, China.

Jiang ChenDepartment of Oral Implantology, Affiliated Stomatological Hospital of Fujian Medical University, Fuzhou, 350002, China. jiangchen@fjmu.edu.cn.

Funding

Fujian Province Natural Science Foundation of China No. 2022J01763Fujian Provincial Health Technology Project No. 2024GGA069Startup Fund for Scientific Research, Fujian Medical University No. 2021QH1135

6 · The paper itself

Abstract

The repair of jawbone defects faces critical challenges, such as the mechanical-bioactivity imbalance and limited bioactivity of traditional scaffold materials. This study proposes a “mechanical reinforcement–bio-mineralization” synergistic strategy to construct a chitin nanowhiskers (CHWs)/octacalcium phosphate (OCP) co-modified chitosan (CS) composite hydrogel (CS/CHWs-OCP) and systematically investigates its bone regeneration efficacy. Results demonstrate the successful fabrication of CS/CHWs-OCP hydrogels with gradient OCP loading (3%–12% wt). The hydrogels exhibit three-dimensional interconnected porous structures, favorable swelling properties, and effective protein loading/sustained-release capabilities. In vitro experiments reveal that CS/CHWs-OCPs significantly promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and angiogenic differentiation of EA.hy926 cells, with the 12 wt% OCP group showing the highest alkaline phosphatase (ALP) activity. Micro-CT 3D reconstruction and histological analysis demonstrate that the 12 wt% OCP group exhibits optimal calvarial defect repair capacity, with its new bone volume fraction (BV/TV: 57.2 ± 10.2%) at 8 weeks being significantly superior to both the blank control and OCP-free hydrogel groups. In conclusion, the developed CS/CHWs-OCP hydrogel provides an effective solution for bone defect regeneration.

Indexed as

Bone regenerationChitin nanowhiskersChitosanOctacalcium phosphate

Identifiers

PMID41851790

DOI10.1186/s13036-026-00647-8

PMCPMC13112624

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.