Evidence map›Paper›PMID 41851667›Full record

ArticleBMC gastroenterology2026

The predictive value of platelet-to-lymphocyte ratio and lymphocyte count in recurrent small intestinal hemorrhage: a retrospective cohort study.

Lu Han, Yiyi Jin, Zide Liu, Chunyan Zeng, Youxiang Chen

Abstract read
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Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lu Han *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, China.
Yiyi Jin *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, China.
Zide LiuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, China.
Chunyan ZengDepartment of Gastroenterology, Jiangxi Province Hospital of Integrated Chinese and Western Medicine, 90 Bayi Road, Xihu District, Nanchang, Jiangxi Province, 330003, China. zengchunyan2024@163.com.
Youxiang ChenDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi, 330006, China. chenyx102@ncu.edu.cn.

Funding

Jiangxi Provincial Natural Science Foundation 20232BAB216018National Natural Science Foundation of China 82360112the Jiangxi Provincial Traditional Chinese Medicine Administration Science and Technology Plan Project 2024A0032
6 · The paper itself

Abstract

backgroundThe recurrence of small intestinal hemorrhage (SIH) poses a significant clinical challenge owing to the absence of reliable and accessible predictive biomarkers. This study aimed to identify a crucial biomarker for predicting SIH recurrence and establish a benchmark to assist clinical decision-making.

methodsThe training cohort comprised 131 newly diagnosed SIH patients who underwent endoscopy at the First Affiliated Hospital of Nanchang University. An independent validation cohort included 96 patients from the Second Affiliated Hospital of Nanchang University. Major variables (MVs) were identified using Least Absolute Shrinkage and Selection Operator (LASSO) regression. A nomogram was developed by incorporating the coefficients of MVs from logistic regression, and its discrimination, calibration, and clinical utility were validated in both cohorts.

resultsDuring one year of follow-up, the bleeding recurrence rates were 41.22% in the training cohort and 30.21% in the validation cohort. Principal causes of bleeding included inflammatory bowel disease, vascular abnormalities, small intestinal diverticula, and small intestinal tumors, among others. The nomogram, based primarily on the Platelet-to-Lymphocyte Ratio (PLR) and Lymphocyte Count (LYM), achieved area under the curve (AUC) values of 0.923 and 0.784 in the training and validation cohorts, respectively. A nomogram score of 37.4 points was preliminarily identified as a potential threshold to distinguish the risk of bleeding recurrence within one year after endoscopic treatment in patients with small intestinal hemorrhage SIH.

conclusionThe nomogram developed in this study provides an effective tool for assessing the risk of recurrence after endoscopic treatment for small intestinal hemorrhage, demonstrating favorable predictive performance and offering a preliminary basis for clinical risk stratification.

Indexed as

Gastrointestinal HemorrhageIntestinal DiseasesIntestine, SmallAdultAgedBiomarkersFemaleHumansLymphocyte CountMaleMiddle AgedNomogramsPlatelet CountPredictive Value of TestsRecurrenceRetrospective StudiesBiomarkersLymphocyte countPlatelet-to-lymphocyte ratioPredictive indicatorsRecurrent gastrointestinal hemorrhageSmall intestinal hemorrhage

Identifiers

PMID41851667
PMCPMC13123161

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.