Evidence map›Paper›PMID 41851636›Full record

ArticleCellular & molecular biology letters2026

NFAT1

Yaochuan Zhang, Xu Cao, Yifu Song, Xiaodi Han, Guofeng Tian, Dongxia Tao, Ana Hou, Sheng Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular biology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yaochuan Zhang *Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Xu Cao *Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Yifu Song *Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Xiaodi HanDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Guofeng TianDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001, China.
Dongxia TaoDepartment of Neurology, The First Hospital of China Medical University, Shenyang, 110001, China. taodongxia@outlook.com.
Ana HouDepartment of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, China. sunnyhou_815@126.com.
Sheng HanDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, 110001, China. hansheng2001_x@aliyun.com.

Funding

Postdoctoral Fellowship Program of China Postdoctoral Science Foundation GZB20250527the National Natural Science Foundation of China nos. 82273482 and 81772653
6 · The paper itself

Abstract

backgroundNeuroinflammation and angiogenesis are central to post-stroke repair. However, the cellular and molecular mechanisms regulating these events remain incompletely understood. The nuclear factor of activated T cells-1 (NFAT1) is implicated in inflammation and vascular remodeling, yet its role in ischemic stroke is unclear.

methodsWe established Nfat1-deficient (Nfat1

resultsNfat1

conclusionsMicroglial NFAT1 drives antiinflammatory polarization and angiogenesis via the HAS3-HA-LYVE1-Wnt/β-catenin axis, ultimately improving stroke recovery. These findings reveal a previously unrecognized mechanism of neurovascular repair and highlight NFAT1

Indexed as

Ischemic StrokeMicrogliaNeovascularization, PhysiologicNFATC Transcription FactorsAnimalsMaleMiceMice, Inbred C57BLSignal TransductionNFATC Transcription FactorsAngiogenesisCell therapyHAS3Ischemic strokeLYVE1MicrogliaNeuroinflammationNFAT1Wnt/β-catenin

Identifiers

PMID41851636
PMCPMC13281348

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.