ReviewCurrent neuropharmacology2026
Use of Single Prolonged Stress to Model Post-traumatic Stress Disorder in Rodents: What We Found and Where to Next?
Review in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Voluntary versus forced exercise modulates anxiety‑like behaviors and hippocampal inflammation gene expression following traumatic stress in rats.IBRO neuroscience reports · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Post-traumatic stress disorder (PTSD) represents a grave and expansive mental illness, caused by experiencing or witnessing traumatic events that invoke profound feelings of helplessness, fear and anxiety. Reflecting the clinical features of PTSD, the single prolonged stress (SPS) model in rodents was developed to elucidate the pathogenesis and identify potential therapeutic interventions. This review aimed to deepen our understanding of the mechanisms and therapeutic methods for PTSD. We conducted a comprehensive literature search on PubMed and Web of Science using keywords such as "SPS", "PTSD", and "mechanisms". Clinical and animal research, especially the exploration of the mechanisms and treatments, were included in this review. We identified a total of 327 articles. After removing duplicates and screening the full texts, we selected only 137 articles. Based on the literature, we examined the parallels and divergences between PTSD and the SPS model regarding symptomatic manifestations, affected brain regions, and molecular markers, demonstrating that the SPS model can effectively replicate PTSD-like behaviors in rodents. Guided by clinical research findings, we further synthesized the mechanisms by which SPS induces PTSD, focusing on the modulation of relevant signaling pathways and neural circuits. Additionally, we reviewed potential intervention strategies for PTSD using this model, encompassing both pharmacological and nonpharmacological therapies. This review offers significant implications for basic research rooted in the clinical characteristics of PTSD, suggesting that studies utilizing the SPS model could enhance our understanding of PTSD and aid in the identification of effective treatment strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.