Evidence map›Paper›PMID 41851580›Full record

ArticleArchives of pharmacal research2026

Nanostructured branched Y-DNA promotes antitumor immunity through dual activation of cGAS/STING and TLR9.

Jin Kyung Seok, Jung In Jee, Jong Han Oh, So Yeon Ahn, Hana Cho, Young Eun Yang, Minhyuk Kim, Hyung-Joo Kwon, Yong-Yeon Cho, Hye Suk Lee and 3 more

Abstract read
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In one paragraph

Article in Archives of pharmacal research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jin Kyung SeokCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Jung In JeeCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Jong Han OhCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
So Yeon AhnSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea.
Hana ChoCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Young Eun YangCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Minhyuk KimCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Hyung-Joo KwonDepartment of Microbiology, College of Medicine, Hallym University, Chuncheon, 24252, Korea.
Yong-Yeon ChoCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Hye Suk LeeCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Soong Ho UmSchool of Chemical Engineering, Sungkyunkwan University, Suwon, 16419, Korea.
Han Chang KangCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea.
Joo Young LeeCollege of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Korea. joolee@catholic.ac.kr.ORCID http://orcid.org/0000-0002-6020-3040

Funding

Catholic University of Korea 2023Catholic University of Korea the Research FundNational Research Foundation of Korea RS-2022-NR067885National Research Foundation of Korea RS-2022-NR068901National Research Foundation of Korea RS-2022-NR072452National Research Foundation of Korea RS-2024-00509796National Research Foundation of Korea RS-2025-00562501
6 · The paper itself

Abstract

Effective activation of innate and adaptive immunity remains a major challenge in cancer immunotherapy. In this study, we aimed to develop an immunostimulatory oligonucleotides for antitumor immunotherapy. We designed branched Y-shaped DNA (Yb-DNA) nanoparticles complexed with a reducible polycationic carrier (RPC-bPEI

Indexed as

Antineoplastic AgentsDNAMembrane ProteinsNanostructuresNucleotidyltransferasesToll-Like Receptor 9AnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDendritic CellsFemaleImmunotherapyLung NeoplasmsMelanoma, ExperimentalMiceMice, Inbred C57BLAntineoplastic AgentscGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAMembrane ProteinsNucleotidyltransferasesSting1 protein, mouseSTING ProteinTlr9 protein, mouseToll-Like Receptor 9Toll-Like Receptor AgonistscGASCombination therapyImmune activationNanomedicineToll-like receptorTumor microenvironment

Identifiers

PMID41851580
PMCPMC13076375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.