ArticleAntonie van Leeuwenhoek2026
Comparative genomic assessment of probiotic potential across the Anoxybacillaceae family.
Article in Antonie van Leeuwenhoek, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Thermotolerant and thermophilic bacteria have recently attracted interest as potential next-generation probiotics due to their intrinsic resistance to environmental and technological stresses. Within this context, the family Anoxybacillaceae has emerged as a promising reservoir of candidates. The aim of this study was to assess this potential through a family-level comparative genomics approach. A comparative genomic analysis was conducted on 68 bacterial genomes, including 30 clinically validated probiotic reference strains and 38 Anoxybacillaceae genomes. A curated probiotic functional marker set was assembled and calibrated. From 204 candidate markers, 101 conserved markers were retained following genome-wide screening and lineage-based filtering. Marker detection relied on a consensus-based homology framework integrating DIAMOND and HMMER, generating weighted confidence scores. Complementary analyses of biosynthetic gene clusters, carbohydrate-active enzyme-associated functions (CAZymes), genomic safety features, and mobilome components were performed.Weighted functional marker profiles significantly discriminated probiotics from Anoxybacillaceae (PERMANOVA, Bray-Curtis R
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