ArticleVirchows Archiv : an international journal of pathology2026
Mucosal melanoma of the head and neck region: clinical-pathologic implications of tumor microenvironment evaluated with multiplex immunohistochemistry.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mucosal melanoma of the head and neck (MM-H&N) is an aggressive disease known for its frequent residual tumor/relapses (RT/R) at the surgical site, which encourages the need for additional therapeutical strategies. Our current understanding of the tumor microenvironment (TME) in MM-H&N and its correlation with clinical-pathologic, immunohistochemical, and molecular features, remains far less comprehensive than that of its cutaneous counterpart. Additionally, the TME composition of consecutive samples collected from single patients has not been investigated, which limits our ability to detail the prognosis and therapy of these patients. Thirty-eight MM-H&N specimens from 24 patients were analyzed using a four-label protocol of bright-field multiplex immunohistochemistry (IHC) with CD20 (purple), CD3 (DAB-brown), CD68 (green), and SOX10 (yellow). The cases were assessed using a previously validated score, dichotomized into low and high adopting the corresponding median values, and statistically correlated with clinical-pathological, immunohistochemical, and molecular features (χ
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