Evidence map›Paper›PMID 41851478›Full record

ArticleNature neuroscience2026

Reduced mediodorsal thalamus activity underlies aberrant belief dynamics in a genetic mouse model of schizophrenia.

Tingting Zhou, Yi-Yun Ho, Nolan D Hartley, Ray X Lee, Amanda B Fath, Kathleen He, Xun Yuan, Sam Merrow, Jonathan Scott, Navdeep Bajwa and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Tingting Zhou *Yang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Yi-Yun Ho *Yang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Nolan D HartleyYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4340-3478
Ray X LeeMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Amanda B FathYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Kathleen HeYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Xun YuanYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0009-0004-6897-3287
Sam MerrowYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jonathan ScottDepartment of Neuroscience, Tufts University School of Medicine, Medford, MA, USA.ORCID http://orcid.org/0009-0003-2459-8545
Navdeep BajwaDepartment of Neuroscience, Tufts University School of Medicine, Medford, MA, USA.
Jonathan WildeYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Xian GaoYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Cui LiYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA.
Evan HongMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Zhanyan FuStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9473-2402
Matthew R NassarDepartment of Neuroscience, Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0002-5397-535X
Ralf D WimmerDepartment of Neuroscience, Tufts University School of Medicine, Medford, MA, USA.
Tarjinder SinghStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Michael M HalassaDepartment of Neuroscience, Tufts University School of Medicine, Medford, MA, USA. Michael.Halassa@tufts.edu.ORCID http://orcid.org/0000-0003-1386-0336
Guoping FengYang Tan Collective at MIT and K. Lisa Yang and Hock E. Tan Center for Molecular Therapeutics in Neuroscience, Massachusetts Institute of Technology, Cambridge, MA, USA. fengg@mit.edu.ORCID http://orcid.org/0000-0002-8021-277X

Funding

Genetic and Functional dissection of frontal thalamocortical circuitryR01MH134466 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Guoping Feng, Michael M Halassa · 2023 to 2026
$3.3M
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 31216U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH134466
6 · The paper itself

Abstract

Belief updating is thought to be impaired in schizophrenia, leading to delusions. The neural substrates underlying belief updating are unknown, in part due to a lack of appropriate animal models and behavior readouts. We generated mice bearing a schizophrenia-associated point mutation in Grin2a (Grin2a

Indexed as

Mediodorsal Thalamic NucleusSchizophreniaAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsReceptors, N-Methyl-D-AspartateThalamusReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41851478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.