ArticleNature2026
Thymic health consequences in adults.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance.Journal of human immunity · 2026Article
- Thymic Involution and Function in People With HIV and General Population Controls: A Cross-Sectional Analysis From Two Danish Cohort Studies.Aging cell · 2026Article
- Naive T cell decline limits cancer immunity in middle-aged male mice.Nature aging · 2026Article
- Lymph node contraction links sex-biased naive CD8Nature aging · 2026Article
- Breast cancer immunogenicity as a spectrum: evolving concepts and therapeutic implications.The Journal of clinical investigation · 2026Review
- Why Some People Live Past 100: The Role of the Immune System in Centenarians, Semi-Supercentenarians and Supercentenarians.International journal of molecular sciences · 2026Review
- Thymic health and implications for chronic kidney disease.Nature reviews. Nephrology · 2026Article
- The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire.Aging cell · 2026Article
- Long-Term Cancer and Mortality After Thymectomy.European journal of neurology · 2026Article
- Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life.European journal of immunology · 2026Article
- Thymulin restrains age-associated myeloid inflammation and enhances cancer immunotherapy.Nature communications · 2026Article
- Article
- Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Immunological Drug-Drug Interactions in Immune Checkpoint Inhibitor Therapy: Mechanisms, Clinical Evidence, and Artificial Intelligence.Current oncology reports · 2026Review
- Senescence of T cells and organ aging.Inflammation and regeneration · 2026Review
- Article
- Radiographic evidence of thymic involution in hepatocellular carcinoma: a propensity score-matched study in viral cirrhosis.Frontiers in immunology · 2026Article
- Vitamin D signaling in thymic development and longevity.Frontiers in nutrition · 2026Article
- Immunosuppression after pediatric liver transplantation may lead to early and prolonged acute thymic involution: findings from a pilot longitudinal study.Frontiers in immunology · 2026Article
- Network-orchestrated regulation of thymic dysfunction and restoration.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Simon Bernatz *Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7758-8100
Vasco Prudente *Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0623-1259
Suraj Pai *Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.
Asbjørn K AttermannArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0006-3307-0031
Yumeng CaoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jiachen ChenDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1941-2326
Asya LyassDepartment of Mathematics and Statistics, Boston University, Boston, MA, USA.
Borek FoldynaArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.
Leonard NürnbergArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6544-4268
Keno BressemArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.
Christopher AbboshCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-8983-1382
Charles SwantonCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0002-4299-3018
Mariam Jamal-HanjaniCancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.ORCID http://orcid.org/0000-0003-1212-1259
Michael T LuArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA.
Joanne M MurabitoFramingham Heart Study, National Heart, Lung and Blood Institute and Boston University Chobanian and Avedisian School of Medicine, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-0192-7516
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9268-810X
Nicolai J BirkbakDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-1613-9587
Hugo J W L AertsArtificial Intelligence in Medicine (AIM) Program, Mass General Brigham & Harvard Medical School, Boston, MA, USA. haerts@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-2122-2003
Funding
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MThe Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2MUnraveling the Complexities of Risk and Mechanism in CancerR35CA220523 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI QUACKENBUSH, JOHN · 2018 to 2024
$6.0MQuantitative Radiomics System Decoding the Tumor PhenotypeU24CA194354 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.5MRole of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring StudyR01AG067457 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DOYLE, MARGARET F., LUNETTA, KATHRYN L · 2020 to 2024
$3.4MGenotype and Imaging Phenotype Biomarkers in Lung CancerU01CA190234 · NCI · DANA-FARBER CANCER INST · PI AERTS, HUGO, QUACKENBUSH, JOHN · 2015 to 2019
$3.3MDevelopment of an artificial intelligence-driven, imaging-based platform for pretreatment identification of extranodal extension in head and neck cancerK08DE030216 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI KANN, BENJAMIN HARRIS · 2021 to 2025
$841kIntegrating Multi-Omics to Uncover Shared Mechanisms Linking Physical Frailty and Alzheimer's Disease: Inflammation and Relevant PathwaysF99AG095040 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHEN, JIACHEN · 2025 to 2025
$49kNCI NIH HHS R35 CA220523NCI NIH HHS U01 CA190234NCI NIH HHS U01 CA209414NCI NIH HHS U24 CA194354NHLBI NIH HHS 75N92019D00031NIA NIH HHS F99 AG095040NIA NIH HHS R01 AG067457NIDCR NIH HHS K08 DE030216
Abstract
The thymus is essential for establishing T cell diversity early in life, but undergoes profound involution with age and has therefore traditionally been regarded as largely nonfunctional in adults
Indexed as
AgingThymus GlandAdultAgedCardiovascular DiseasesCohort StudiesFemaleHumansIncidenceInflammationLongevityLung NeoplasmsMaleMiddle AgedProspective StudiesSmoking
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.