Evidence map›Paper›PMID 41851464›Full record

ArticleNature2026

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation.

Jakob Farnung, Elena Slobodyanyuk, Peter Y Wang, Lianne W Blodgett, Daniel H Lin, Susanne von Gronau, Brenda A Schulman, David P Bartel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. TheNon-coding RNA · 2026
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jakob Farnung *Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-4619-3421
Elena Slobodyanyuk *Howard Hughes Medical Institute, Cambridge, MA, USA.ORCID 0000-0003-2077-6917
Peter Y WangHoward Hughes Medical Institute, Cambridge, MA, USA.ORCID 0000-0002-6129-2815
Lianne W BlodgettHoward Hughes Medical Institute, Cambridge, MA, USA.ORCID 0009-0002-3060-0704
Daniel H LinHoward Hughes Medical Institute, Cambridge, MA, USA.ORCID 0000-0002-1393-3374
Susanne von GronauDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.
Brenda A SchulmanDepartment of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany. schulman@biochem.mpg.de.ORCID 0000-0002-3083-1126
David P BartelHoward Hughes Medical Institute, Cambridge, MA, USA. dbartel@wi.mit.edu.ORCID 0000-0002-3872-2856

Funding

Post-transcriptional gene regulationR35GM118135 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DAVID P BARTEL · 2016 to 2026
$10.7M
NIGMS NIH HHS R35 GM118135
6 · The paper itself

Abstract

MicroRNAs (miRNAs) associate with Argonaute (AGO) proteins to form complexes that down-regulate target RNAs, including messenger RNAs from most human genes

Indexed as

MicroRNAsProteolysisRNA StabilityUbiquitin-Protein LigasesAnimalsArgonaute ProteinsCullin ProteinsHumansMiceProtein BindingUbiquitinationArgonaute ProteinsCUL3 protein, humanCullin ProteinsMicroRNAsUbiquitin-Protein Ligases

Identifiers

PMID41851464
PMCPMC13083262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.