Evidence map›Paper›PMID 41851462›Full record

ArticleNature2026

Biosynthesis of cinchona alkaloids.

Blaise Kimbadi Lombe, Tingan Zhou, Gyumin Kang, Joshua C Wood, John P Hamilton, Klaus Gase, Yoko Nakamura, Ryan M Alam, Ron P Dirks, Lorenzo Caputi and 2 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Cinchona alkaloid scaffold decoded.Plant communications · 2026
    Article
  2. Tuning reductase activity in monoterpene indole alkaloid biosynthesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. How Cinchona builds quinine.Nature chemical biology · 2026
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Blaise Kimbadi Lombe *Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0003-4298-3108
Tingan Zhou *Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0001-5269-0283
Gyumin KangDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
Joshua C WoodCenter for Applied Genetic Technologies, University of Georgia, Athens, GA, USA.
John P HamiltonCenter for Applied Genetic Technologies, University of Georgia, Athens, GA, USA.
Klaus GaseDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0002-8028-5645
Yoko NakamuraDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0002-9622-1005
Ryan M AlamDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
Ron P DirksFuture Genomics Technologies, Leiden, The Netherlands.
Lorenzo CaputiDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.
C Robin BuellCenter for Applied Genetic Technologies, University of Georgia, Athens, GA, USA. Robin.Buell@uga.edu.ORCID http://orcid.org/0000-0002-6727-4677
Sarah E O'ConnorDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany. oconnor@ice.mpg.de.ORCID http://orcid.org/0000-0003-0356-6213

Funding

Multi-omics approaches to lower the barriers to sustainable production of plant natural products with relevance to human healthR01AT012783 · NCCIH · UNIVERSITY OF GEORGIA · PI Carol Robin Buell · 2024 to 2026
$1.5M
NCCIH NIH HHS R01 AT012783
6 · The paper itself

Abstract

Cinchona alkaloids, which have been studied for more than 250 years, are plant-derived natural products that have collectively had a substantial impact in medicine and basic science

Indexed as

Biosynthetic PathwaysCinchona AlkaloidsNicotianaCyclizationGene SilencingHalogenationIsotope LabelingQuinolinesTranscriptomeTryptaminesCinchona AlkaloidsQuinolinesTryptamines

Identifiers

PMID41851462
PMCPMC13149305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.