Evidence map›Paper›PMID 41851460›Full record

ArticleNature2026

Climbing fibres recruit disinhibition to enhance Purkinje cell calcium signals.

Fernando Santos-Valencia, Elizabeth P Lackey, Aliya Norton, Asem Wardak, Cole S Gaynor, Sean Ediger, Marie E Hemelt, Tri M Nguyen, Wei-Chung Allen Lee, Nicolas Brunel and 2 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fernando Santos-Valencia *Department of Neurobiology, Duke University Medical School, Durham, NC, USA.ORCID http://orcid.org/0000-0002-8906-0397
Elizabeth P Lackey *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2191-1239
Aliya Norton *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Asem Wardak *Department of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0048-1484
Cole S GaynorDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Sean EdigerDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Marie E HemeltDepartment of Neurobiology, Duke University Medical School, Durham, NC, USA.
Tri M NguyenDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Wei-Chung Allen LeeDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4618-295X
Nicolas BrunelDepartment of Neurobiology, Duke University Medical School, Durham, NC, USA.
Court A HullDepartment of Neurobiology, Duke University Medical School, Durham, NC, USA. Hull@neuro.duke.edu.ORCID http://orcid.org/0000-0002-0360-8367
Wade G RegehrDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. wade_regehr@hms.harvard.edu.ORCID http://orcid.org/0000-0002-3485-8094

Funding

Cerebellar circuits for reward-based learningR01NS128054 · NINDS · DUKE UNIVERSITY · PI COURT A HULL · 2022 to 2026
$1.9M
Circuit Specializations of Cerebellar Molecular Layer InterneuronsF32NS133036 · NINDS · HARVARD MEDICAL SCHOOL · PI LACKEY, ELIZABETH · 2023 to 2025
$202k
NINDS NIH HHS F32 NS133036NINDS NIH HHS R01 NS128054
6 · The paper itself

Abstract

Climbing fibre (CF) inputs to Purkinje cells (PCs) instruct plasticity and learning in the cerebellum

Indexed as

Calcium SignalingNerve FibersNeural InhibitionPurkinje CellsAnimalsCerebellumDendritesFemaleGlutamic AcidInterneuronsLearningMaleMiceMice, Inbred C57BLNeuronal PlasticitySynapsesGlutamic Acid

Identifiers

PMID41851460
PMCPMC13171427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.