ArticleNature2026
Catabolism of extracellular glutathione supplies cysteine to support tumours.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Activatable NIR-II photoacoustic probes for cancer imaging and imaging-guided therapy.Bioactive materials · 2026Review
- Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026Review
- Cysteine excess triggers a mitochondrial iron-dependent cell death.Nature metabolism · 2026Article
- Organic Nanozyme-Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-Omics Analysis Reveals Molecular Networks and Key Pathways Associated with Cysteine- and Methionine-Mediated Biosynthesis of Sulfur-Containing Flavor Metabolites inInternational journal of molecular sciences · 2026Article
- Review
- A potent alternative cysteine production pathway allows reductase independence.Nature chemical biology · 2026Article
- The Methionine-Mitochondria Axis in Cancer: Metabolic Cross-Talk and Therapeutic Vulnerabilities.Current pharmacology reports · 2026Review
Corrections and comments
- Update of
Authors and funding
36 authors.
Fabio Hecht *Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. fabio_hechtcastromedeiro@urmc.rochester.edu.ORCID http://orcid.org/0000-0001-9110-2587
Marco Zocchi *Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0009-0001-3531-3045
Emily T TuttleDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Nathan P WardDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
Fatemeh AlimohammadiDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Amal Afzal KhanDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0009-0001-4904-1976
Veronica C GomesDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Bradley SmithWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0009-0006-4812-4258
Jennifer J TwardowskiWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-1366-2738
Bradley N MillsWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
Kevin A WelleUniversity of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, USA.
Sina GhaemmaghamiUniversity of Rochester Mass Spectrometry Resource Laboratory, Rochester, NY, USA.
Zhuoran ZhouDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0009-0002-7973-6215
Yuhan GanDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Yun Pyo KangDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0002-1149-0880
Juliana CazarinDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-5728-1857
Zamira G SoaresDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Mete Emir OzgursesDepartment of Physiology and Biophysics, University of Illinois College of Medicine, University of Illinois Cancer Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8472-3948
Huiping ZhaoDepartment of Physiology and Biophysics, University of Illinois College of Medicine, University of Illinois Cancer Center, Chicago, IL, USA.
Colin SheehanBen May Department of Cancer Research, University of Chicago, Chicago, IL, USA.
Guillaume CognetBen May Department of Cancer Research, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5427-8110
Lila D MungerDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Dhvani TrivediDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Gloria AsantewaaDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Sara K Blick-NitkoDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Jason J ZoellerDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3531-2111
Ying ChenDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.
Vasilis VasiliouDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2552-3118
Bradley M TurnerDepartment of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
Stephano S MelloDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.
Brian J AltmanDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0002-3954-4916
Alexander MuirBen May Department of Cancer Research, University of Chicago, Chicago, IL, USA.
Jonathan L ColoffDepartment of Physiology and Biophysics, University of Illinois College of Medicine, University of Illinois Cancer Center, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-4726-3097
Joshua MungerWilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.ORCID http://orcid.org/0000-0001-5379-9440
Gina M DeNicolaDepartment of Metabolism and Physiology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6611-6696
Isaac S HarrisDepartment of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. isaac_harris@urmc.rochester.edu.ORCID http://orcid.org/0000-0002-6855-2763
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restricting amino acids from tumours is an emerging therapeutic strategy with substantial promise
Indexed as
CysteineExtracellular SpaceGlutathioneNeoplasmsAnimalsCell Line, TumorCell SurvivalCystineFemalegamma-GlutamyltransferaseHumansMaleMiceTumor MicroenvironmentCysteineCystinegamma-GlutamyltransferaseGlutathione
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.