Evidence map›Paper›PMID 41851437›Full record

ArticleNature chemical biology2026

A family portrait of lanmodulin selectivity for enhanced rare-earth separations.

Patrick Diep, Cody S Madsen, Wonseok Choi, Ziye Dong, Christina S Kang-Yun, Patricia F V Uychoco, Jeremy A Seidel, Samuel A Eaton, Yongqin Jiao, Joseph A Cotruvo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Patrick DiepBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.ORCID http://orcid.org/0000-0001-9403-3206
Cody S MadsenBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.ORCID http://orcid.org/0000-0003-2737-2210
Wonseok ChoiDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0009-0005-7051-6605
Ziye DongBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Christina S Kang-YunBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.ORCID http://orcid.org/0000-0001-5536-3253
Patricia F V UychocoBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Jeremy A SeidelBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Samuel A EatonDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA.ORCID http://orcid.org/0000-0001-7992-4641
Yongqin JiaoBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.ORCID http://orcid.org/0000-0002-6798-5823
Joseph A CotruvoDepartment of Chemistry, The Pennsylvania State University, University Park, PA, USA. juc96@psu.edu.ORCID http://orcid.org/0000-0003-4243-8257
Dan M ParkBiosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA. park36@llnl.gov.ORCID http://orcid.org/0000-0002-6000-6805

Funding

United States Department of Defense | Defense Advanced Research Projects Agency (DARPA) DE-AC52-07NA27344
6 · The paper itself

Abstract

Proteins offer a molecular design space to create bespoke ligands for the separation of critical metals like rare earth elements (REs). However, data-intensive approaches to tune metalloprotein selectivity are constrained by the low-throughput nature of existing characterization methods. Here we invented an assay called 'SpyTag-Catcher Immobilization of Lanmodulin for Assaying Metal-Binding Selectivity' (SpyCI-LAMBS) to measure metalloprotein selectivity en masse. This 96-format workflow was used to study the selectivity of 621 lanmodulin (LanM) orthologs for 15 REs, revealing eight distinct selectivity profiles based on sequence-to-function analyses. We discovered >200 LanMs with stronger selectivity against low-value La

Indexed as

MetalloproteinsMetals, Rare EarthLigandslanmodulinLigandsMetalloproteinsMetals, Rare Earth

Identifiers

PMID41851437
PMCPMC13128445

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.