Evidence map›Paper›PMID 41851351›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Clinical feature analysis of pediatric Castleman disease with renal involvement.

Yue Xi, Jiafeng Yao, Zhi Chen, Ying Liang, Rui Zhang, Nan Zhou

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue XiDepartment of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Jiafeng YaoHematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Zhi ChenDepartment of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Ying LiangDepartment of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Rui ZhangHematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. ruizh1973@126.com.
Nan ZhouDepartment of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. zhounan11@sina.com.ORCID http://orcid.org/0000-0002-6118-171X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric Castleman disease (CD) is a rare lymph node disorder, and renal involvement is uncommon in pediatric CD. This study aimed to investigate the clinical features of pediatric CD with renal involvement.

methodsClinical data from Beijing Children's Hospital for pediatric patients with CD were analyzed retrospectively. All included cases were confirmed by lymph node biopsy, with one patient also undergoing renal biopsy.

resultsA total of 42 pediatric patients with CD were included, of whom 20 (47.6%) presented with renal involvement, with a median age of 10.9 years. Renal manifestations included proteinuria (11 cases), acute nephritis (4 cases), nephrotic syndrome (2 cases), and acute renal failure (3 cases). Renal involvement generally coincided with CD onset and improved following etiological treatment of CD. One patient who underwent renal biopsy was diagnosed with minimal change disease. Notably, isolated nephrotic syndrome could occur during the remission phase of CD, presenting as steroid-resistant disease that responded to the addition of immunosuppressive agents.

conclusionsPediatric CD with renal involvement included proteinuria, nephrotic syndrome, acute nephritis, and acute renal failure. Renal involvement occurred simultaneously with CD and improved rapidly in all patients after etiological treatment of CD and immunosuppressants.

Indexed as

Acute Kidney InjuryCastleman DiseaseKidneyNephritisNephrotic SyndromeProteinuriaAdolescentBiopsyChildChild, PreschoolFemaleHumansImmunosuppressive AgentsLymph NodesMaleRetrospective StudiesImmunosuppressive AgentsCastleman diseaseChildrenClinical featuresRenal involvement

Identifiers

PMID41851351

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