Evidence map›Paper›PMID 41851343›Full record

ArticleEMBO reports2026

The AICL-KLRF1 axis supports CD4-CD8 T cell communication and cytokine competence in pre-exhausted CD8

Matthias Barone, Stefan Peidli, Anika Neuschulz, Karla Riesterer, Christina Iwert, Laia Junquera, Somesh Sai, Olufemi Bolaji, Diana Bakoueva, Christine Appelt and 6 more

Abstract read
In one paragraph

Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Matthias Barone *Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6554-6464
Stefan Peidli *Institute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-4257-8690
Anika NeuschulzBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-6163-3344
Karla RiestererBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.
Christina IwertBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.
Laia JunqueraBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0009-0006-9259-0213
Somesh SaiMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.ORCID 0000-0001-6865-341X
Olufemi BolajiBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.
Diana BakouevaBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.
Christine AppeltBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0009-0000-7865-9911
Benedikt ObermayerCore Unit Bioinformatics (CUBI), Berlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.
Bertram KlingerInstitute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-0242-1506
Alexandra TrinksBioportal Single Cells, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117, Berlin, Germany.
Anja SieberInstitute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-6588-8547
Nils BlüthgenInstitute of Pathology, Charité, Charité Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-0171-7447
Birgit SawitzkiBerlin Institute of Health (BIH) at Charité, Charité Universitätsmedizin Berlin, Berlin, Germany. birgit.sawitzki@bih-charite.de.ORCID 0000-0001-8166-8579

Funding

Bundesministerium für Forschung, Technologie und Raumfahrt (BMBF) FKZ 01EP2201 NKSGBundesministerium für Forschung, Technologie und Raumfahrt (BMBF) FKZ 01KX2021 COVIMBundesministerium für Forschung, Technologie und Raumfahrt (BMBF) FKZ 01KX2121 RAPIDBundesministerium für Forschung, Technologie und Raumfahrt (BMBF) FKZ 02NUK086ECharité - Universitätsmedizin Berlin (Medical School - Charité - University Medicine Berlin) 3R projectDeutsche Forschungsgemeinschaft (DFG) CRC 1444 project 427826188Deutsche Forschungsgemeinschaft (DFG) KFO BECAUSE-Y project SA 1383/4-1:Deutsche Forschungsgemeinschaft (DFG) RTG2424Deutsche Forschungsgemeinschaft (DFG) SA1383/3-1EC | European Research Council (ERC) MSCA TOP-GUT project B8000303Volkswagen Foundation (VolkswagenStiftung) Swarm Learning project 8000354
6 · The paper itself

Abstract

Memory-like or precursor exhausted (Tpex) CD8

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell CommunicationCytokinesLectins, C-TypeCell DifferentiationHumansLung NeoplasmsReceptors, ImmunologicSignal TransductionT-Cell ExhaustionCytokinesKLRG1 protein, humanLectins, C-TypeReceptors, ImmunologicCytotoxic T CellKLRF1T Cell ExhaustionTumor Immunology

Identifiers

PMID41851343
PMCPMC13121605

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.