Evidence map›Paper›PMID 41851340›Full record

ReviewMolecular psychiatry2026

Autism spectrum disorder across the lifespan: Dynamic symptom trajectories and multidimensional support framework.

Yifei Wang, Renjun Lv, Ziying Jiang, Yitong Liu, Jingliang Zhang, Ziqian Zhao, Yue Liu, Yongbo Zheng, Bin Liu, Daniel Clauw and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Review
  2. [Focusing on profound autism: validity of clinical taxonomy and management of treatment-resistant symptoms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yifei Wang *Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Renjun Lv *Department of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Ziying Jiang *Department of Neurology, Xuanwu Hospital, National Center for Neurological Disorders, Capital Medical University, Beijing, China.
Yitong LiuInstitute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Jingliang ZhangDepartment of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Ziqian ZhaoInstitute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yue LiuInstitute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yongbo ZhengInstitute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.ORCID http://orcid.org/0000-0002-5314-5364
Bin LiuDepartment of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Neuroimmunology, Jinan, Shandong, China.
Daniel ClauwDepartments of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Jie SunDepartments of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. jiesu@umich.edu.
Lin LuInstitute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. linlu@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-0742-9072
Qingqing YinDepartment of Geriatric Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. yinqingqing@sdfmu.edu.cn.ORCID http://orcid.org/0000-0001-7181-4763

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism Spectrum Disorder (ASD) is a complex and highly heterogeneous neurodevelopmental condition, typically emerging in early childhood and persisting throughout life. Its core symptoms-social communication deficits and restricted, repetitive sensory-motor patterns-exhibit dynamic trajectories across developmental stages, with distinct challenges arising at different ages. While substantial research efforts have been dedicated to pediatric ASD, the scientific focus remains comparatively limited for adult and geriatric populations, leaving their distinct needs less comprehensively addressed. This review begins with a concise overview of the epidemiology and etiology of ASD. We then examine age-dependent symptom evolution and associated challenges across the lifespan, from childhood to advanced age. Finally, we propose a stage-specific, individualized life-course support framework, outlining tailored strategies for distinct developmental phases. This framework transcends symptomatic management to empower functional resilience across the life trajectory, offering a roadmap for research and practice to serve the entire autism spectrum.

Indexed as

Autism Spectrum DisorderAdultChildHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.