ArticleAnnals of hematology2026
Treatment of Burkitt lymphoma in real-world setting: findings on 104 consecutive cases diagnosed and treated in Kazakhstan over the last decade.
Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We investigated treatment outcomes, relapse risk, and survival in 104 consecutive patients with non-endemic Burkitt lymphoma (BL) diagnosed and treated in Kazakhstan between 2013 and 2024 in a real-world setting. This was a retrospective, clinically based study analyzing baseline characteristics, treatment regimens, response to first-line therapy, prognostic factors, relapse, and survival. The median age was 26 years (range 2–80), with a male predominance (64%). All cases underwent MYC rearrangement assessment, and EBV status was available in 80 patients, with 28% testing positive. Curative-intent therapy was delivered to 95 patients (91%), including R-BFM (44%), R-EPOCH (23%), R-CODOX-M/R-IVAC (18%), and R-Hyper-CVAD (15%); no patient underwent autologous stem cell transplantation. After a median follow-up of 57 months, the 3-year overall survival (OS) and progression-free survival (PFS) were 57% and 56%, respectively. Patients younger than 18 years, all treated with R-BFM, had significantly superior outcomes compared with adults, with 3-year OS and PFS of 82% and 83%, respectively (p < 0.001). Among adults, patients treated with R-Hyper-CVAD or R-CODOX-M/R-IVAC had better OS than those treated with R-EPOCH (50% vs. 19%, p = 0.04). In univariate analysis, age ≥ 40 years, female sex, ECOG performance status ≥ 2, and platelet count < 150 g/dL were associated with inferior prognosis. In multivariate analysis, age ≥ 40 years remained the only independent adverse prognostic factor. The adapted Burkitt Lymphoma International Prognostic Index retained prognostic value. In conclusion, this large real-world study demonstrates excellent outcomes in pediatric patients treated with intensive immunochemotherapy but substantially inferior results in adults, particularly in refractory disease, highlighting a critical unmet clinical need in this population.
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