Evidence map›Paper›PMID 41851205›Full record

ArticleScientific data2026

Genome assembly and annotation of the naked mole rat Heterocephalus glaber reared in Japan.

Kouhei Toga, Kaori Oka, Hiroyuki Tanaka, Takehiko Itoh, Atsushi Toyoda, Hidemasa Bono, Kyoko Miura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific data, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kouhei TogaLaboratory of BioDX, PtBio Co-Creation Research Center, Genome Editing Innovation Center, Hiroshima University, 3-10-23 Kagamiyama, Higashi-Hiroshima city, Hiroshima, 739-0046, Japan.
Kaori OkaDepartment of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto city, Kumamoto, 860-0811, Japan.
Hiroyuki TanakaDepartment of Life Science and Technology, Institute of Science Tokyo, Tokyo, 152-8550, Japan.
Takehiko ItohDepartment of Life Science and Technology, Institute of Science Tokyo, Tokyo, 152-8550, Japan.ORCID http://orcid.org/0000-0002-6113-557X
Atsushi ToyodaComparative Genomics Laboratory, National Institute of Genetics, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.ORCID http://orcid.org/0000-0002-0728-7548
Hidemasa BonoLaboratory of BioDX, PtBio Co-Creation Research Center, Genome Editing Innovation Center, Hiroshima University, 3-10-23 Kagamiyama, Higashi-Hiroshima city, Hiroshima, 739-0046, Japan. bonohu@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0003-4413-0651
Kyoko MiuraDepartment of Aging and Longevity Research, Faculty of Life Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto city, Kumamoto, 860-0811, Japan. miura.kyoko.314@m.kyushu-u.ac.jp.ORCID http://orcid.org/0000-0003-2208-149X

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJFR216CMEXT | Japan Science and Technology Agency (JST) JPMJPF2010MEXT | Japan Society for the Promotion of Science (JSPS) JP18H02365MEXT | Japan Society for the Promotion of Science (JSPS) JP24H00542
6 · The paper itself

Abstract

The naked mole rat (NMR, Heterocephalus glaber) is a eusocial rodent that is native to northeastern Africa. NMRs exhibit extraordinary traits such as longevity, resistance to age-related decline, and remarkable hypoxia tolerance. Although the reference genome of this species has been determined because of its unique characteristics, the significance or role of intraspecific genomic variations remains unknown. In this study, we used PacBio long-read sequencing to generate a genome assembly of NMR reared in Japan. The assembled genome is 2.56 Gb. Benchmarking Universal Single-Copy Orthologs (BUSCO) revealed high completeness (95.2%). BRAKER3 estimated 26,714 protein-coding genes, and we successfully added functional annotations for 26,232 protein-coding genes using the functional annotation workflow. We identified 417 gene models that were previously undetectable in the reference genome of this species. We also identified structural and amino acid sequence variations between our assembly and the reference genome, suggesting the presence of intraspecific genomic variations. This new genomic resource could help uncover the molecular mechanisms underlying the behavioral and physiological traits of NMR.

Indexed as

GenomeMole RatsAnimalsDatasets as TopicJapanMolecular Sequence Annotation

Identifiers

PMID41851205
PMCPMC13149982

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.