Articlenpj aging2026
Avoidance of rejuvenation: a stress test for evolutionary theories of aging.
Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
The biological feasibility of human rejuvenation remains a subject of intense debate, yet answering this question is critical for guiding research strategies. Should aging research focus only on reversing aging in older individuals, or pausing its progression at mid-ages, be more accessible? Here, we attempt to address this question with evolutionary biology. Rejuvenation occurs in a few species, and, paradoxically, is typically induced by stress but not used under optimal conditions. Using mathematical modeling of lifespan plasticity in eusocial insects that can rejuvenate, we show that avoidance of rejuvenation is poorly explained by classic theories of aging in their standard formulations, requiring substantial assumptions to fit them. By contrast, one of the programmed theories of aging-the pathogen control hypothesis-offers a consistent evolutionary framework for understanding avoidance of rejuvenation. Moreover, our model mathematically predicts the evolution of the genetic program executing lifespan termination - adaptive aging mechanisms.
Identifiers
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Registered trials
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