Evidence map›Paper›PMID 41851141›Full record

ArticleNPJ science of food2026

Dietary rhythms and biological aging risk across multiple organs.

Luyan Zheng, Zhilong Jia, Shuanghui Gong, Tian Zheng, Yizhou Zhuang, Lan Lin, Qianwen Li, Fan Lin, Meixia Ren

Abstract read
In one paragraph

Article in NPJ science of food, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luyan Zheng *Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Zhilong Jia *Medical Innovation Research Division of Chinese PLA General Hospital, Beijing, China.
Shuanghui GongShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Tian ZhengShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Yizhou ZhuangShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Lan LinShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Qianwen LiShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Fan LinShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. linfan@fjmu.edu.cn.
Meixia RenShengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. m.ren@fzu.edu.cn.

Funding

Fujian Provincial Health Commission Young and Middle-aged Key Talent Training Program 2025GGA003the National Natural Sciences Foundation of China 81800364the Natural Science Foundation of Fujian 2025J01081
6 · The paper itself

Abstract

The effects of dietary rhythms on organ-specific biological aging remain unclear. This study analyzed 14,012 adults from NHANES to assess associations between dietary rhythms and biological aging of the body, heart, liver, and kidneys. Earlier last meals, specifically before 9 p.m., were linked to lower aging risks for the body, heart, and liver but not kidneys. The strongest protective effects were seen with meals between 3 and 5 p.m. for the body and heart, and 5-7 p.m. for the liver. Conversely, later first meals and longer feeding durations (>8 h) linked to higher aging risks. These associations were modified by age, gender, disease status, caloric intake and dietary quality, with effects more pronounced in individuals over 40, males, and those without existing diseases or with low calorie intake. Delayed first and earlier last meal remained significantly associated with body and liver aging in the healthy diet group, whereas heart aging showed stronger associations with meal time in the unhealthy diet group. This study revealed optimal meal timing and duration differ for biological aging across different organs, ages, genders, disease status, energy intake, and dietary quality, highlighting a critical food-nutrient-timing synergy, and the need for personalized nutritional guidance and population-specific dietary strategies.

Identifiers

PMID41851141
PMCPMC13153295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.