Evidence map›Paper›PMID 41851086›Full record

ArticleCell death & disease2026

DUSP12 promotes cell cycle progression and protects cells from ZNF622 mediated apoptosis.

Mai Abdusamad, Xiao Guo, Ivan Ramirez, Erick F Velasquez, Whitaker Cohn, Ankur A Gholkar, Immy A Ashley, Yennifer Delgado, Mehdi Bouhaddou, Julian P Whitelegge and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mai AbdusamadDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Xiao GuoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Ivan RamirezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Erick F VelasquezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Whitaker CohnPasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Ankur A GholkarDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Immy A AshleyMolecular Biology Institute, University of California, Los Angeles, CA, USA.
Yennifer DelgadoMolecular Biology Institute, University of California, Los Angeles, CA, USA.
Mehdi BouhaddouMolecular Biology Institute, University of California, Los Angeles, CA, USA.
Julian P WhiteleggePasarow Mass Spectrometry Laboratory, The Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Robert DamoiseauxJonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7611-7534
Jorge Z TorresDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA. jorget@ucla.edu.ORCID http://orcid.org/0000-0002-2158-889X

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
MULTIDISCIPLINARY TRAINING IN MICROBIAL PATHOGENESIST32AI007323 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peter John Bradley · 1988 to 2026
$8.6M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
Investigating the Cell Division MachineryR35GM139539 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 2021 to 2025
$2.2M
Viral Biosensors of Host Post-Translational ModificationsR35GM160071 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Mehdi Bouhaddou · 2025 to 2026
$842k
Defining the role of DUSP12 in the regulation of cell division and apoptosis.F31GM154466 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABDUSAMAD, MAI · 2024 to 2025
$66k
National Science Foundation (NSF) DGE-2444110NIGMS NIH HHS R35 GM139539NIGMS NIH HHS T32 GM145388U.S. Department of Health & Human Services | National Institutes of Health (NIH) R35GM160071U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI007323U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) P30DK063491U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) F31GM154466U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM139539U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM145388U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) P30CA016042
6 · The paper itself

Abstract

Protein phosphatases are critical for regulating cell signaling, cell cycle, and cell fate decisions, and their dysregulation leads to an array of human diseases like cancer. The dual specificity phosphatases (DUSPs) have emerged as important factors driving tumorigenesis and cancer therapy resistance. DUSP12 is a poorly characterized atypical DUSP widely conserved throughout evolution. Although no direct substrate has been firmly established, DUSP12 has been implicated in protecting cells from stress, regulating ribosomal biogenesis, and modulating cellular DNA content. In this study, we used affinity- and proximity-based biochemical purification approaches coupled to mass spectrometry to identify the zinc finger protein ZNF622 as a novel DUSP12 interactor, which was validated by in cell and in vitro IP assays. Interestingly, ZNF622 binds to the unique zinc-binding domain of DUSP12, which previous reports indicated was important for many of DUSP12's functions within the cell. Prior studies had implicated ZNF622 as a modulator of apoptosis, but it remained unclear if and how ZNF622 participated in the cell cycle and, more so, how it promoted cell death. Using mass spectrometry analyses, we found that overexpression of DUSP12 promoted de-phosphorylation of ZNF622 at Ser

Indexed as

ApoptosisCell CycleDual-Specificity PhosphatasesHEK293 CellsHumansProtein BindingDual-Specificity Phosphatases

Identifiers

PMID41851086
PMCPMC13039736

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.