Evidence map›Paper›PMID 41851046›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Association of family and friend relationship satisfaction with incident dementia: A prospective cohort study of 104,093 participants.

Dandan Sheng, Ting Yang, Yuye Ning, Meilin Chen, Zhibo Wang, Yumei Liang, Siqi Xie, Lan Ding, Jianping Jia

Abstract read
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Dandan ShengInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Ting YangInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Yuye NingInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Meilin ChenInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Zhibo WangInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Yumei LiangInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Siqi XieInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Lan DingInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Jianping JiaInnovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.ORCID 0000-0003-4624-0336

Funding

Beijing Brain Initiative from Beijing Municipal Science & Technology CommissionChinese Institutes for Medical ResearchSTI2030-Major Projects
6 · The paper itself

Abstract

introductionFamily relationships and friendships are important for cognitive health, yet how their quality relates to dementia risk remains poorly understood.

methodsThis prospective cohort study included 104,093 UK Biobank participants aged 40 to 69 years who were dementia free within the first 4 years. Relationship satisfaction was categorized as satisfied or dissatisfied. Cox regression models assessed associations.

resultsOver 13.56 years, 1359 developed dementia. In the fully adjusted model, dissatisfied (vs. satisfied) family relationships were associated with elevated dementia risk (hazard ratio [HR]: 1.334, 95% confidence interval [CI]: 1.069-1.663), driven primarily by very dissatisfied participants (HR: 1.663). Friendship dissatisfaction showed no significant association with dementia risk (HR: 1.060, 95% CI: 0.752-1.494). Overall relationship dissatisfaction was associated with increased dementia risk (HR 1.265, 95% CI 1.035-1.546), though becoming non-significant after adjustment for additional psychological factors. DISCUSSION: Family relationship quality may represent a risk factor of dementia warranting consideration in prevention strategies.

Indexed as

DementiaFamilyFamily RelationsFriendsPersonal SatisfactionAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsUnited Kingdomcognitive healthdementiafamily relationshipsfriendship satisfactionrelationship quality

Identifiers

PMID41851046
PMCPMC13093783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.