Evidence map›Paper›PMID 41850854›Full record

ArticleThe Journal of veterinary medical science2026

Evaluation of the efficacy and safety of a modified anesthetic protocol using dexmedetomidine, midazolam, and butorphanol in mice.

Natsuki Kida, Haruto Takeda, Kazuhiro Sakamoto, Masaki Watanabe, Nobuya Sasaki, Atsushi Asano

Abstract read
In one paragraph

Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natsuki KidaLaboratory of Laboratory Animal Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Haruto TakedaLaboratory of Laboratory Animal Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Kazuhiro SakamotoLaboratory of Laboratory Animal Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Masaki WatanabeLaboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Nobuya SasakiLaboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, Aomori, Japan.
Atsushi AsanoLaboratory of Laboratory Animal Science, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to evaluate the efficacy and safety of a modified injectable anesthesia protocol combining dexmedetomidine, midazolam, and butorphanol (dMMB) compared with the conventional medetomidine-based protocol (MMB) in C57BL/6J mice. Animals were assigned to three groups (n=5 per group for each sex): MMB (0.5/4.0/5.0), dMMB (0.25/4.0/5.0), and dMMB (0.1/6.0/10.0) mg/kg. We assessed anesthetic induction and recovery times, depth scores, heart rate, SpO

Indexed as

AnesthesiaAnesthetics, CombinedButorphanolDexmedetomidineHypnotics and SedativesMidazolamAnesthesia Recovery PeriodAnimalsBlood GlucoseBody TemperatureFemaleHeart RateMaleMedetomidineMiceMice, Inbred C57BLAnesthetics, CombinedBlood GlucoseButorphanolDexmedetomidineHypnotics and SedativesMedetomidineMidazolamanimal welfarebutorphanoldexmedetomidineinjectable anesthesiamidazolam

Identifiers

PMID41850854
PMCPMC13183499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.