Evidence map›Paper›PMID 41850723›Full record

ArticleLife science alliance2026

Huntingtin (HTT) interactome in regulation of DNA repair/remodeling and RNA processing pathways.

Tamara Ratovitski, Chloe D Holland, Robert N O'Meally, Alexey V Shevelkin, Siddhi V Kamath, Tianze Shi, Matthew J Rodriguez, Robert N Cole, Mali Jiang, Christopher A Ross

Abstract read
In one paragraph

Article in Life science alliance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Tamara RatovitskiDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA tratovi1@jhmi.edu.ORCID 0000-0003-4020-5644
Chloe D HollandDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert N O'MeallyMass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexey V ShevelkinDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Siddhi V KamathDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tianze ShiDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0008-2373-9349
Matthew J RodriguezDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0000-5415-0168
Robert N ColeMass Spectrometry and Proteomics Facility, Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mali JiangDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christopher A RossDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA caross@jhu.edu.ORCID 0000-0003-1882-5847

Funding

Targeting Protein Arginine Methylation in HDR21NS109412 · NINDS · JOHNS HOPKINS UNIVERSITY · PI RATOVITSKI, TAMARA · 2019 to 2020
$450k
NINDS NIH HHS R01 NS08645208NINDS NIH HHS R21 NS109412
6 · The paper itself

Abstract

Huntington's disease (HD), an uncurable neurodegenerative disorder, is caused by CAG repeat expansion in the

Indexed as

DNA RepairHuntingtin ProteinRNA Processing, Post-TranscriptionalAnimalsChromatin Assembly and DisassemblyDNA-Activated Protein KinaseDNA Breaks, Double-StrandedDNA DamageHumansHuntington DiseaseMiceNeuronsPhosphorylationDNA-Activated Protein KinaseHTT protein, humanHuntingtin Protein

Identifiers

PMID41850723
PMCPMC13000123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.