ArticleBMJ open gastroenterology2026
Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank.
Article in BMJ open gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Authors and funding
8 authors.
Funding
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Abstract
objectiveColorectal cancer (CRC) and cardiovascular disease (CVD) share common risk factors. This study explores the association between cardiovascular health (CVH), assessed using the Life's Essential 8 (LE8) score, and CRC risk, while examining the modifying roles of genetic predisposition and colonoscopy screening.
methodsA total of 291 177 UK Biobank participants were included in the analysis. LE8 comprises eight indicators: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. Cox proportional hazards models were used for analysis.
resultsDuring a median follow-up of 12.97 years, 3791 incident CRC cases were identified. Compared with low LE8 scores, high LE8 scores were associated with a 26% reduced CRC risk (HR: 0.74; 95% CI 0.64 to 0.86). High LE8 was linked to a 27% lower CRC risk in individuals with high genetic risk (HR: 0.73; 95% CI 0.56 to 0.94) and a 35% reduction in those without a history of colonoscopy screening (HR: 0.65; 95% CI 0.54 to 0.78). Joint analysis showed a 78% lower CRC risk in those with high LE8 and low genetic risk (HR: 0.22; 95% CI 0.15 to 0.34).
conclusionBetter CVH is associated with a reduced risk of CRC, particularly in individuals with high genetic susceptibility and those without a history of colonoscopy screening.
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