ArticleClinical medicine (London, England)2026
Clinical predictors of malignancy in lymphadenopathy: A multivariable analysis from a quick diagnosis unit.
Article in Clinical medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Hypertension: A common, yet poorly managed condition. What can we do better?Clinical medicine (London, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeripheral lymphadenopathy (LA) has diverse causes and may indicate malignancy, particularly in referred patients.
aimTo characterise patients referred for unexplained LA to a quick diagnosis unit, and identify independent predictors of malignancy. DESIGN AND
methodsWe conducted a retrospective study of 485 consecutive adults evaluated for unexplained LA between 2017 and 2023. The primary outcome was malignancy. Secondary outcomes included diagnostic delay and time to oncology referral. Demographic, clinical and laboratory variables were compared across aetiological groups. A parsimonious multivariable logistic regression model included five clinically relevant predictors identified in univariable analyses and supported by biological plausibility.
resultsMedian age was 46 years, and time to first visit was 11 days. Cervical nodes were most frequent (51.9%), followed by supraclavicular (18.6%). Malignancy was diagnosed in 20.8% of patients, with diagnostic delay of 26.5 days (15.5-42). Other specific diagnoses were established in 35.5% of cases, while 43.7% were reactive. Malignant cases were older (60.8 vs 42 years), predominantly male (68.3% vs 44.5%), had higher drug exposure (50.0% vs 29.8%), and shorter symptom duration (45 vs 90 days). In multivariable analysis, independent predictors of malignancy were: age (odds ratio (OR) 1.71 per 10-year increase), male sex (OR 3.25), lymph node size (OR 1.36 per 5 mm increase), indurated consistency (OR 3.42), and supraclavicular location (OR 4.96). Median time to oncology evaluation was 47 days.
conclusionThe QDU model enables timely diagnosis and detects malignancy in over 20% of cases. Recognising clinical predictors may help prioritise high-risk patients and streamline diagnostic pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.