Evidence map›Paper›PMID 41850396›Full record

ArticleMolecular metabolism2026

IGF-1 and insulin receptors in LepRb neurons jointly regulate body growth, bone mass, reproduction, and metabolism.

Mengjie Wang, Piotr J Czernik, Beata Lecka-Czernik, Jennifer W Hill

Abstract read
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In one paragraph

Article in Molecular metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mengjie WangCenter for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA; Center for Molecular Psychiatry, Department of Psychiatry and Behavioral Science, University of South Florida, Tampa, FL, USA.
Piotr J CzernikCenter for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA.
Beata Lecka-CzernikCenter for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA; Department of Orthopedic Surgery, University of Toledo College of Medicine, Toledo, OH, USA.
Jennifer W HillCenter for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA; Department of Obstetrics and Gynecology, University of Toledo College of Medicine, Toledo, OH, USA; Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH, USA. Electronic address: jenniferw.hill@utoledo.edu.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Leptin receptor (LepRb)-expressing neurons integrate metabolic and reproductive signals, yet the role of insulin-like growth factor 1 receptor (IGF1R) signaling within these neurons remains unclear. Because IGF-1 and insulin can partially activate each other's receptors, we generated mice lacking IGF1R selectively in LepRb neurons (IGF1R

Indexed as

Bone and BonesNeuronsReceptor, IGF Type 1Receptor, InsulinSignal TransductionAnimalsBone DevelopmentEnergy MetabolismFemaleFertilityGlucoseMaleMiceMice, KnockoutPubertyReceptors, LeptinGlucoseIgf1r protein, mouseReceptor, IGF Type 1Receptor, InsulinReceptors, LeptinBone metabolismEnergy balanceHypothalamusIGF1 receptorInsulin receptorLepRb neuronsNeuroendocrine regulationReproductive function

Identifiers

PMID41850396
PMCPMC13054536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.