A Sugaromics Method for Combined Targeted and Untargeted Sugar Profiling: Fit-for-Purpose Validation of a Quantitative GC × GC-MS Approach.

Elisa E Streitenberger, Björn Egert, Lara Frommherz, Sabine E Kulling, Carina I Mack

Abstract readValidation Study

In one paragraph

Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Elisa E StreitenbergerDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut., Haid-und-Neu-Straße 9, 76131 Karlsruhe, Germany.ORCID 0009-0006-0016-658X

Björn EgertDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut., Haid-und-Neu-Straße 9, 76131 Karlsruhe, Germany.

Lara FrommherzDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut., Haid-und-Neu-Straße 9, 76131 Karlsruhe, Germany.

Sabine E KullingDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut., Haid-und-Neu-Straße 9, 76131 Karlsruhe, Germany.ORCID 0000-0002-9956-2702

Carina I MackDepartment of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut., Haid-und-Neu-Straße 9, 76131 Karlsruhe, Germany.ORCID 0000-0001-8617-7947

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The composition of sugar compounds in human biofluids is affected by various factors, including diet, health, demographic background, and lifestyle. Accurate quantification of this profile enables identification and application of biomarkers linked to health and nutrition, offering valuable insights into the mechanistic background of sugar metabolism. However, existing methods typically quantify only a few sugar compounds simultaneously, constraining full assessment of the sugar profile. Hence, we propose a comprehensive two-dimensional gas chromatography coupled with a mass spectrometry-based detector sugaromics method applying a nonpolar-medium polar column setup. The method is a combination of a targeted and untargeted approach to absolutely quantify various sugars in urine (

Indexed as

Gas Chromatography-Mass SpectrometrySugarsHumansSugars

Identifiers

PMID41850295

DOI10.1021/acs.analchem.5c04230

PMCPMC13044882

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