Evidence map›Paper›PMID 41850282›Full record

ArticleCurrent biology : CB2026

Simultaneous path-integration recalibration in head direction and place cells.

Ravikrishnan P Jayakumar, Yotaro Sueoka, Marissa K Ferreyros, Brian Y Li, Manu S Madhav, Xingyu Chen, James J Knierim, Noah J Cowan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ravikrishnan P JayakumarZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: rperurj1@jhu.edu.
Yotaro SueokaZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: ysueoka1@jhu.edu.
Marissa K FerreyrosZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Brian Y LiZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Manu S MadhavZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD 21218, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
Xingyu ChenUndergraduate Program in Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA.
James J KnierimZanvyl Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: jknierim@jhu.edu.
Noah J CowanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA; Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, MD 21218, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: ncowan@jhu.edu.

Funding

A Control Theoretic Approach to Addressing Hippocampal FunctionR01NS102537 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Noah John Cowan, JAMES J KNIERIM · 2017 to 2026
$3.6M
CRCNS: Path Intergration by the Grid Cell NetworkR01MH079511 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLAIR, HUGH T, KNIERIM, JAMES J · 2006 to 2015
$3.0M
CRCNS: Dynamics of Gain Recalibration in the Hippocampal-Entorhinal Path Integration SystemR01MH118926 · NIMH · JOHNS HOPKINS UNIVERSITY · PI COWAN, NOAH JOHN, HEDRICK, KATHRYN · 2018 to 2022
$1.8M
NIMH NIH HHS R01 MH079511NIMH NIH HHS R01 MH118926NINDS NIH HHS R01 NS102537
6 · The paper itself

Abstract

Accurate spatial navigation relies on path integration, a process of tracking one's location by integrating self-motion cues. Path integration uses a gain factor relating self-motion signals to displacement on the cognitive map. This gain is plastic, recalibrating rapidly to match perceived displacements relative to external cues. To elucidate the mechanism of recalibration, we simultaneously recorded from place cells, which instantiate the cognitive map, and head direction (HD) cells, thought to orient the map. Persistent conflict between self-motion and visual feedback induced functionally identical recalibration of path-integration gain in the two neural populations during forward locomotion; however, during locomotor immobility accompanied by head scanning, HD cells did not exhibit recalibration. Moreover, the two populations manifested differential field-shifting dynamics relative to landmarks during recalibration. These results uncover a tightly coordinated yet behavior-dependent recalibration process across the navigation circuit that achieves robust yet flexible coupling of the internal sense of position and direction.

Indexed as

Place CellsSpatial NavigationAnimalsCuesLocomotionMaleRatsRats, Long-Evanscue conflictfield shifthead direction cellshead-scanningLong-Evans ratpath integrationplace cellsrecalibrationspatial navigation

Identifiers

PMID41850282
PMCPMC13484491

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.