Evidence map›Paper›PMID 41850231›Full record

ArticleCell reports. Medicine2026

pH-regulating Lipiodol Pickering emulsions enhance transarterial embolization therapy via inducing ferroptosis and activating antitumor immunity.

Weihao Yang, Chunjie Wang, Chao Yu, Nan Jiang, Bin Yu, Yicheng Ni, Caifang Ni, Liangzhu Feng, Lei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Weihao YangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Chunjie WangInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.
Chao YuCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Nan JiangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Bin YuDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Yicheng NiCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China.
Caifang NiDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. Electronic address: szncf@suda.edu.cn.
Liangzhu FengInstitute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China. Electronic address: lzfeng@suda.edu.cn.
Lei ZhangCenter of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Department of Radiology, Zhongda Hospital, Medical School, Southeast University, No. 87 Dingjiaqiao Road, Nanjing 210009, China. Electronic address: zhang_lei@seu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter arterial chemoembolization (TACE) faces limitations in hepatocellular carcinoma (HCC) due to suboptimal drug pharmacokinetics and immunosuppression post-embolization. This study develops iron nanoparticles (FeNPs) with pH-responsive Fenton activity as surfactants for a Lipiodol Pickering emulsion (LPE) to deliver cariporide, targeting tumor acidity. Cariporide inhibits plasma membrane sodium-hydrogen exchangers, reducing intracellular pH to amplify FeNP-induced ferroptosis while suppressing extracellular acidosis by blocking proton extrusion. The cariporide-loaded FeNP-LPE (CFe-LPE) promotes immunogenic cell death and reverses immunosuppressive tumor microenvironments by alleviating acidity. In multiple orthotopic HCC models, CFe-LPE-based transarterial embolization outperforms conventional doxorubicin-Lipiodol TACE, demonstrating that dual modulation of intra/extracellular pH enhances Fenton-catalytic embolic agents by synergistically activating antitumor immunity.

Indexed as

Carcinoma, HepatocellularChemoembolization, TherapeuticEthiodized OilFerroptosisLiver NeoplasmsAnimalsCell Line, TumorDoxorubicinEmulsionsHumansHydrogen-Ion ConcentrationIronMiceTumor MicroenvironmentDoxorubicinEmulsionsEthiodized OilIronferroptosisLipiodol Pickering emulsiontransarterial embolizationtumor acidity regulationtumor immunosuppression

Identifiers

PMID41850231
PMCPMC13006419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.