Evidence map›Paper›PMID 41849889›Full record

ArticleBiosensors & bioelectronics2026

Artifact-free, colocalized opto-electrophysiology enabled by a flexible, multimodal interface integrating transparent MXene microelectrodes and microLEDs.

Royce Dong, Yuzhang Chen, Raghav Garg, Spencer R Averbeck, Chris Wun, Placid Unegbu, Sneha Shankar, Shereen Ahmad, Jimin Jung, Md Abu Zahed and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Royce DongDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Yuzhang ChenCenter for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Raghav GargCenter for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Spencer R AverbeckDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Chris WunDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Placid UnegbuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Sneha ShankarDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Shereen AhmadCenter for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Jimin JungDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.
Md Abu ZahedCenter for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Danzhen ZhangA. J. Drexel Nanomaterials Institute, and Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, USA.
Yury GogotsiA. J. Drexel Nanomaterials Institute, and Department of Materials Science and Engineering, Drexel University, Philadelphia, PA, USA.
Hajime TakanoDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Brian LittDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Flavia VitaleDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA; Center for Neurotrauma, Neurodegeneration, and Restoration, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA; Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: vitalef@pennmedicine.upenn.edu.

Funding

Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Optimizing Optogenetics for Cell-type-specific Control in Freely-moving PrimatesR01NS123054 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MICHAEL L PLATT · 2022 to 2026
$2.9M
Validating MXene Electrodes for Next-Generation ElectroencephalographyR01NS121219 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MEDAGLIA, JOHN, VITALE, FLAVIA · 2021 to 2025
$2.3M
Studying stimulation of long-range cortical projections involved in visual-spatial behavior in non-human primates with a novel multimodal optoelectronic deviceF30EY037143 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Royce Dong · 2025 to 2026
$93k
NEI NIH HHS F30 EY037143NINDS NIH HHS R01 NS121219NINDS NIH HHS R01 NS123054NINDS NIH HHS T32 NS091006
6 · The paper itself

Abstract

Neurotechnologies capable of both modulating and recording neural activity are critical for investigating neural function and disease. Optoelectronic probes incorporating micro-light-emitting diodes (μLEDs) and transparent microelectrodes enable colocalized optogenetic stimulation and electrophysiological recordings with high spatiotemporal resolution but often suffer from stimulation artifacts. In this work, we present a thin, flexible, and conformal neural interface integrating blue μLEDs (460 nm) with transparent Ti

Indexed as

Biosensing TechniquesOptogeneticsAnimalsArtifactsEquipment DesignMiceMicroelectrodesNeuronsNitritesTitaniumTransition ElementsMXeneNitritesTitaniumTransition ElementsArtifact-freeMicroLEDMXeneNeurophysiologyOptogeneticsTransparent electrodes

Identifiers

PMID41849889
PMCPMC13173954

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.