ReviewCurrent opinion in structural biology2026
Toward a unifying mechanistic model of eukaryotic translation initiation through integrative single-molecule, structural, and computational insights.
Review in Current opinion in structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- 40S ribosomal subunits move along the 5' UTR through an eIF4A-independent mechanism in higher eukaryotes.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
During eukaryotic translation initiation, initiation factor proteins and the ribosomal small subunit undergo binding and dissociation reactions and conformational rearrangements that properly assemble a ribosome at the start codon of a messenger RNA. Building on extensive genetic and biochemical studies, single-molecule fluorescence experiments are revealing the time-dependent pathways of factor binding to, and dissociation from, the ribosomal small subunit and messenger RNA during initiation. Nonetheless, essential binding and/or dissociation events, conformational rearrangements, and the coupling between binding and conformational changes remain kinetically uncharacterized. Here, we summarize the status of single-molecule investigations of initiation and advocate for integrating single-molecule microscopy, structural biology, and molecular simulations to enable a time-dependent, molecular description of this fundamental step in gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.