Observational studyJCO precision oncology2026
Genomic Features and Response to Poly(ADP-ribose) Polymerase Inhibition in Metastatic Castration-Resistant Prostate Cancer.
Observational study in JCO precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
23 authors.
Funding
Abstract
purposePoly(ADP-ribose) polymerase inhibitors (PARPis) are effective for the treatment of metastatic castration-resistant prostate cancer (mCRPC) harboring homologous recombination repair (HRR) gene alterations, but predictive biomarkers beyond individual gene alterations remain poorly defined. We aimed to identify genomic features associated with response to PARP inhibition in real-world data. MATERIALS AND
methodsThis is a single-center retrospective study of patients with mCRPC who received PARPi therapy. All patients underwent tumor genomic profiling using a single panel sequencing assay. Responses were defined as prostate-specific antigen (PSA50) (≥50% PSA decline from baseline) and objective radiographic response by RECIST 1.1. We explored the association of genomic features with response to therapy.
resultsAmong 120 patients with mCRPC who received a PARPi, 54% had
conclusionMost PARPi responders had alterations in HRR genes, particularly
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