Evidence map›Paper›PMID 41849400›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Imported, not invented, genes prevail among

Md Hassan Uz-Zaman, Howard Ochman

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Md Hassan Uz-ZamanDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-3929-247X
Howard OchmanDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712.ORCID 0000-0003-1688-7059

Funding

Elucidating the Evolution of Microbial Genes, Genomes and CommunitiesR35GM118038 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI OCHMAN, HOWARD · 2016 to 2025
$4.0M
HHS | NIH (NIH) R35GM118038NIGMS NIH HHS R35 GM118038
6 · The paper itself

Abstract

Bacterial genomes contain numerous ORFans-genes lacking homologs outside the species in which they are found. The source of these genes remains enigmatic because the major mechanism by which new genes originate-by duplication and divergence-is rare in bacteria. The proposed explanations for the birth of ORFan genes include horizontal transfer from sources unrepresented in the databases and rapid divergence from preexisting sequences; however, the lack of direct homology-based evidence has left this issue unresolved. We curated a high-confident set of

Indexed as

Escherichia coliGenes, BacterialOpen Reading FramesEvolution, MolecularGene Transfer, HorizontalGenome, BacterialPhylogenyde novo gene birthhorizontal gene transferorphan genepangenomeproto-gene

Identifiers

PMID41849400
PMCPMC13012023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.